The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells

Notch1 is required to generate the earliest embryonic hematopoietic stem cells (HSCs); however since Notch-deficient embryos die early in gestation, additional functions for Notch in embryonic HSC biology have not been described. We used two complementary genetic models to address this important bio...

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Detalles Bibliográficos
Autores principales: Gerhardt, Dawson M., Pajcini, Kostandin V., D’altri, Teresa, Tu, LiLi, Jain, Rajan, Xu, Lanwei, Chen, Michael J., Rentschler, Stacey, Shestova, Olga, Wertheim, Gerald B., Tobias, John W., Kluk, Michael, Wood, Antony W., Aster, Jon C., Gimotty, Phyllis A., Epstein, Jonathan A., Speck, Nancy, Bigas, Anna, Pear, Warren S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967047/
https://www.ncbi.nlm.nih.gov/pubmed/24637115
http://dx.doi.org/10.1101/gad.227496.113

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