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Association of MDR1 G2677T polymorphism and leukemia risk: evidence from a meta-analysis

In the light of the relationship between the MDR1 G2677T polymorphism and the risk of leukemia remains inclusive or controversial. For better understanding of the effect of MDR1 G2677T polymorphism on leukemia risk, we performed a meta-analysis. Eligible studies were identified through a search of e...

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Autores principales: Yan, Yulan, Liang, Hongjie, Xie, Li, He, Yu, Li, Meng, Li, Ruolin, Li, Shan, Qin, Xue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967080/
https://www.ncbi.nlm.nih.gov/pubmed/24142546
http://dx.doi.org/10.1007/s13277-013-1291-0
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author Yan, Yulan
Liang, Hongjie
Xie, Li
He, Yu
Li, Meng
Li, Ruolin
Li, Shan
Qin, Xue
author_facet Yan, Yulan
Liang, Hongjie
Xie, Li
He, Yu
Li, Meng
Li, Ruolin
Li, Shan
Qin, Xue
author_sort Yan, Yulan
collection PubMed
description In the light of the relationship between the MDR1 G2677T polymorphism and the risk of leukemia remains inclusive or controversial. For better understanding of the effect of MDR1 G2677T polymorphism on leukemia risk, we performed a meta-analysis. Eligible studies were identified through a search of electronic databases such as PubMed, Excerpta Medica Database (Embase), Cochrane Library, and Chinese Biomedical Literature Database (CBM). The association between the MDR1 G2677T polymorphism and leukemia risk was conducted by odds ratios (ORs) and 95 % confidence intervals (95 % CI). A total of seven publications including eight studies with 1,229 cases and 1,097 controls were included in the meta-analysis. There was no association between MDR1 G2677T polymorphism and leukemia risk in all of five models in overall populations (T vs. G: OR = 1.00, 95 % CI = 0.88–1.12, P = 0.914; TT vs. GG: OR = 0.97, 95 % CI = 0.75–1.26, P = 0.812; TG vs. GG: OR = 1.00, 95 % CI = 0.92–1.08, P = 0.939; TT vs. TG/GG: OR = 0.98, 95 % CI = 0.67–1.43, P = 0.906; TT/TG vs. GG: OR = 1.00, 95 % CI = 0.95–1.06, P = 0.994). However, the significant association was found in others (Table 2) under the homozygote model (TT vs. GG: OR = 0.68, 95 % CI = 0.48–0.94, P = 0.020) and recessive model (TT vs. TG/GG: OR = 0.63, 95 % CI = 0.43–0.92, P = 0.016). In the subgroup analysis, according to the type of leukemia, significant association was found between MDR1 G2677T polymorphism and myeloid leukemia but not lymphoblastic leukemia (TT vs. GG: OR = 0.66, 95 % CI = 0.46–0.95, P = 0.026; TT vs. TG/GG: OR = 0.56, 95 % CI = 0.38–0.84, P = 0.005). The results suggested that there was no association between MDR1 G2677T polymorphism and leukemia risk in overall populations, but significant association was found in others populations (Asians and Africans), and myeloid leukemia indicated that G2677T polymorphism might be a protective factor in the susceptibility of myeloid leukemia and in Asians and Africans.
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spelling pubmed-39670802014-03-27 Association of MDR1 G2677T polymorphism and leukemia risk: evidence from a meta-analysis Yan, Yulan Liang, Hongjie Xie, Li He, Yu Li, Meng Li, Ruolin Li, Shan Qin, Xue Tumour Biol Research Article In the light of the relationship between the MDR1 G2677T polymorphism and the risk of leukemia remains inclusive or controversial. For better understanding of the effect of MDR1 G2677T polymorphism on leukemia risk, we performed a meta-analysis. Eligible studies were identified through a search of electronic databases such as PubMed, Excerpta Medica Database (Embase), Cochrane Library, and Chinese Biomedical Literature Database (CBM). The association between the MDR1 G2677T polymorphism and leukemia risk was conducted by odds ratios (ORs) and 95 % confidence intervals (95 % CI). A total of seven publications including eight studies with 1,229 cases and 1,097 controls were included in the meta-analysis. There was no association between MDR1 G2677T polymorphism and leukemia risk in all of five models in overall populations (T vs. G: OR = 1.00, 95 % CI = 0.88–1.12, P = 0.914; TT vs. GG: OR = 0.97, 95 % CI = 0.75–1.26, P = 0.812; TG vs. GG: OR = 1.00, 95 % CI = 0.92–1.08, P = 0.939; TT vs. TG/GG: OR = 0.98, 95 % CI = 0.67–1.43, P = 0.906; TT/TG vs. GG: OR = 1.00, 95 % CI = 0.95–1.06, P = 0.994). However, the significant association was found in others (Table 2) under the homozygote model (TT vs. GG: OR = 0.68, 95 % CI = 0.48–0.94, P = 0.020) and recessive model (TT vs. TG/GG: OR = 0.63, 95 % CI = 0.43–0.92, P = 0.016). In the subgroup analysis, according to the type of leukemia, significant association was found between MDR1 G2677T polymorphism and myeloid leukemia but not lymphoblastic leukemia (TT vs. GG: OR = 0.66, 95 % CI = 0.46–0.95, P = 0.026; TT vs. TG/GG: OR = 0.56, 95 % CI = 0.38–0.84, P = 0.005). The results suggested that there was no association between MDR1 G2677T polymorphism and leukemia risk in overall populations, but significant association was found in others populations (Asians and Africans), and myeloid leukemia indicated that G2677T polymorphism might be a protective factor in the susceptibility of myeloid leukemia and in Asians and Africans. Springer Netherlands 2013-10-20 /pmc/articles/PMC3967080/ /pubmed/24142546 http://dx.doi.org/10.1007/s13277-013-1291-0 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by-nc/2.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Research Article
Yan, Yulan
Liang, Hongjie
Xie, Li
He, Yu
Li, Meng
Li, Ruolin
Li, Shan
Qin, Xue
Association of MDR1 G2677T polymorphism and leukemia risk: evidence from a meta-analysis
title Association of MDR1 G2677T polymorphism and leukemia risk: evidence from a meta-analysis
title_full Association of MDR1 G2677T polymorphism and leukemia risk: evidence from a meta-analysis
title_fullStr Association of MDR1 G2677T polymorphism and leukemia risk: evidence from a meta-analysis
title_full_unstemmed Association of MDR1 G2677T polymorphism and leukemia risk: evidence from a meta-analysis
title_short Association of MDR1 G2677T polymorphism and leukemia risk: evidence from a meta-analysis
title_sort association of mdr1 g2677t polymorphism and leukemia risk: evidence from a meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967080/
https://www.ncbi.nlm.nih.gov/pubmed/24142546
http://dx.doi.org/10.1007/s13277-013-1291-0
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