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Vitamin D Receptor Gene Polymorphism and Left Ventricular Hypertrophy in Chronic Kidney Disease

FokI and BsmI polymorphisms of vitamin D receptor (VDR) gene are regarded as reliable markers of disturbed vitamin D signaling pathway. Left ventricular hypertrophy (LVH) is a strong cardiovascular risk marker in end stage renal disease (ESRD) patients. Since BsmI polymorphism has been associated wi...

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Autores principales: Santoro, Domenico, Gagliostro, Giorgia, Alibrandi, Angela, Ientile, Riccardo, Bellinghieri, Guido, Savica, Vincenzo, Buemi, Michele, Caccamo, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967176/
https://www.ncbi.nlm.nih.gov/pubmed/24618509
http://dx.doi.org/10.3390/nu6031029
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author Santoro, Domenico
Gagliostro, Giorgia
Alibrandi, Angela
Ientile, Riccardo
Bellinghieri, Guido
Savica, Vincenzo
Buemi, Michele
Caccamo, Daniela
author_facet Santoro, Domenico
Gagliostro, Giorgia
Alibrandi, Angela
Ientile, Riccardo
Bellinghieri, Guido
Savica, Vincenzo
Buemi, Michele
Caccamo, Daniela
author_sort Santoro, Domenico
collection PubMed
description FokI and BsmI polymorphisms of vitamin D receptor (VDR) gene are regarded as reliable markers of disturbed vitamin D signaling pathway. Left ventricular hypertrophy (LVH) is a strong cardiovascular risk marker in end stage renal disease (ESRD) patients. Since BsmI polymorphism has been associated with LVH in ESRD patients, we addressed this study in patients with chronic kidney disease (CKD) not yet on dialysis. One hundred and forty five patients with CKD stage 3 were genotyped for FokI and BsmI VDR polymorphisms, in order to assess the relationships between these VDR polymorphisms, some markers of mineral bone disorders, and LVH measured by echocardiography. Patients bearing either the Ff heterozygous or FF homozygous genotype had significantly higher PTH values than those bearing the ff genotype. The relationships between VDR genotypes and LVH revealed a highly significant association of the BsmI Bb heterozygous genotype with LVH. In patients with CKD stage 3 BsmI B allele was independently related to LVH. Since LVH is a frequent finding in dialysis population due to several mechanisms, the presence of the same relationship in patients with CKD strengthens the hypothesis that alterations of vitamin D signaling are implicated in LVH development in patients with renal diseases.
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spelling pubmed-39671762014-03-27 Vitamin D Receptor Gene Polymorphism and Left Ventricular Hypertrophy in Chronic Kidney Disease Santoro, Domenico Gagliostro, Giorgia Alibrandi, Angela Ientile, Riccardo Bellinghieri, Guido Savica, Vincenzo Buemi, Michele Caccamo, Daniela Nutrients Article FokI and BsmI polymorphisms of vitamin D receptor (VDR) gene are regarded as reliable markers of disturbed vitamin D signaling pathway. Left ventricular hypertrophy (LVH) is a strong cardiovascular risk marker in end stage renal disease (ESRD) patients. Since BsmI polymorphism has been associated with LVH in ESRD patients, we addressed this study in patients with chronic kidney disease (CKD) not yet on dialysis. One hundred and forty five patients with CKD stage 3 were genotyped for FokI and BsmI VDR polymorphisms, in order to assess the relationships between these VDR polymorphisms, some markers of mineral bone disorders, and LVH measured by echocardiography. Patients bearing either the Ff heterozygous or FF homozygous genotype had significantly higher PTH values than those bearing the ff genotype. The relationships between VDR genotypes and LVH revealed a highly significant association of the BsmI Bb heterozygous genotype with LVH. In patients with CKD stage 3 BsmI B allele was independently related to LVH. Since LVH is a frequent finding in dialysis population due to several mechanisms, the presence of the same relationship in patients with CKD strengthens the hypothesis that alterations of vitamin D signaling are implicated in LVH development in patients with renal diseases. MDPI 2014-03-10 /pmc/articles/PMC3967176/ /pubmed/24618509 http://dx.doi.org/10.3390/nu6031029 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Santoro, Domenico
Gagliostro, Giorgia
Alibrandi, Angela
Ientile, Riccardo
Bellinghieri, Guido
Savica, Vincenzo
Buemi, Michele
Caccamo, Daniela
Vitamin D Receptor Gene Polymorphism and Left Ventricular Hypertrophy in Chronic Kidney Disease
title Vitamin D Receptor Gene Polymorphism and Left Ventricular Hypertrophy in Chronic Kidney Disease
title_full Vitamin D Receptor Gene Polymorphism and Left Ventricular Hypertrophy in Chronic Kidney Disease
title_fullStr Vitamin D Receptor Gene Polymorphism and Left Ventricular Hypertrophy in Chronic Kidney Disease
title_full_unstemmed Vitamin D Receptor Gene Polymorphism and Left Ventricular Hypertrophy in Chronic Kidney Disease
title_short Vitamin D Receptor Gene Polymorphism and Left Ventricular Hypertrophy in Chronic Kidney Disease
title_sort vitamin d receptor gene polymorphism and left ventricular hypertrophy in chronic kidney disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967176/
https://www.ncbi.nlm.nih.gov/pubmed/24618509
http://dx.doi.org/10.3390/nu6031029
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