Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106

Two unusual pyridones, trichodin A (1) and trichodin B (2), together with the known compound, pyridoxatin (3), were extracted from mycelia and culture broth of the marine fungus, Trichoderma sp. strain MF106 isolated from the Greenland Seas. The structures of the new compounds were characterized as...

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Autores principales: Wu, Bin, Oesker, Vanessa, Wiese, Jutta, Schmaljohann, Rolf, Imhoff, Johannes F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967205/
https://www.ncbi.nlm.nih.gov/pubmed/24663111
http://dx.doi.org/10.3390/md12031208
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author Wu, Bin
Oesker, Vanessa
Wiese, Jutta
Schmaljohann, Rolf
Imhoff, Johannes F.
author_facet Wu, Bin
Oesker, Vanessa
Wiese, Jutta
Schmaljohann, Rolf
Imhoff, Johannes F.
author_sort Wu, Bin
collection PubMed
description Two unusual pyridones, trichodin A (1) and trichodin B (2), together with the known compound, pyridoxatin (3), were extracted from mycelia and culture broth of the marine fungus, Trichoderma sp. strain MF106 isolated from the Greenland Seas. The structures of the new compounds were characterized as an intramolecular cyclization of a pyridine basic backbone with a phenyl group. The structure and relative configuration of the new compounds were established by spectroscopic means. The new compound 1 and the known compound 3 showed antibiotic activities against the clinically relevant microorganism, Staphylococcus epidermidis, with IC(50) values of 24 μM and 4 μM, respectively.
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spelling pubmed-39672052014-03-27 Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106 Wu, Bin Oesker, Vanessa Wiese, Jutta Schmaljohann, Rolf Imhoff, Johannes F. Mar Drugs Article Two unusual pyridones, trichodin A (1) and trichodin B (2), together with the known compound, pyridoxatin (3), were extracted from mycelia and culture broth of the marine fungus, Trichoderma sp. strain MF106 isolated from the Greenland Seas. The structures of the new compounds were characterized as an intramolecular cyclization of a pyridine basic backbone with a phenyl group. The structure and relative configuration of the new compounds were established by spectroscopic means. The new compound 1 and the known compound 3 showed antibiotic activities against the clinically relevant microorganism, Staphylococcus epidermidis, with IC(50) values of 24 μM and 4 μM, respectively. MDPI 2014-03-06 /pmc/articles/PMC3967205/ /pubmed/24663111 http://dx.doi.org/10.3390/md12031208 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Wu, Bin
Oesker, Vanessa
Wiese, Jutta
Schmaljohann, Rolf
Imhoff, Johannes F.
Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106
title Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106
title_full Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106
title_fullStr Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106
title_full_unstemmed Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106
title_short Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106
title_sort two new antibiotic pyridones produced by a marine fungus, trichoderma sp. strain mf106
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967205/
https://www.ncbi.nlm.nih.gov/pubmed/24663111
http://dx.doi.org/10.3390/md12031208
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