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White matter integrity is associated with alcohol cue reactivity in heavy drinkers

Neuroimaging studies have shown that white matter damage accompanies excessive alcohol use, but the functional correlates of alcohol-related white matter disruption remain unknown. This study applied tract-based spatial statistics (TBSS) to diffusion tensor imaging (DTI) data from 332 heavy drinkers...

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Autores principales: Monnig, Mollie A, Thayer, Rachel E, Caprihan, Arvind, Claus, Eric D, Yeo, Ronald A, Calhoun, Vince D, Hutchison, Kent E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Periodicals, Inc. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967532/
https://www.ncbi.nlm.nih.gov/pubmed/24683509
http://dx.doi.org/10.1002/brb3.204
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author Monnig, Mollie A
Thayer, Rachel E
Caprihan, Arvind
Claus, Eric D
Yeo, Ronald A
Calhoun, Vince D
Hutchison, Kent E
author_facet Monnig, Mollie A
Thayer, Rachel E
Caprihan, Arvind
Claus, Eric D
Yeo, Ronald A
Calhoun, Vince D
Hutchison, Kent E
author_sort Monnig, Mollie A
collection PubMed
description Neuroimaging studies have shown that white matter damage accompanies excessive alcohol use, but the functional correlates of alcohol-related white matter disruption remain unknown. This study applied tract-based spatial statistics (TBSS) to diffusion tensor imaging (DTI) data from 332 heavy drinkers (mean age = 31.2 ± 9.4; 31% female) to obtain averaged fractional anisotropy (FA) values of 18 white matter tracts. Statistical analyses examined correlations of FA values with blood-oxygenation-level-dependent (BOLD) response to an alcohol taste cue, measured with functional magnetic resonance imaging (fMRI). FA values of nine white matter tracts (anterior corona radiata, body of corpus callosum, cingulate gyrus, external capsule, fornix, inferior frontooccipital fasciculus, posterior corona radiata, retrolenticular limb of internal capsule, and superior longitudinal fasciculus) were significantly, negatively correlated with BOLD activation in medial frontal gyrus, parahippocampal gyrus, fusiform gyrus, cingulum, thalamus, caudate, putamen, insula, and cerebellum. The inverse relation between white matter integrity and functional activation during the alcohol taste cue provides support for the hypothesis that lower white matter integrity in frontoparietal and corticolimbic networks is a factor in loss of control over alcohol consumption.
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spelling pubmed-39675322014-03-28 White matter integrity is associated with alcohol cue reactivity in heavy drinkers Monnig, Mollie A Thayer, Rachel E Caprihan, Arvind Claus, Eric D Yeo, Ronald A Calhoun, Vince D Hutchison, Kent E Brain Behav Original Research Neuroimaging studies have shown that white matter damage accompanies excessive alcohol use, but the functional correlates of alcohol-related white matter disruption remain unknown. This study applied tract-based spatial statistics (TBSS) to diffusion tensor imaging (DTI) data from 332 heavy drinkers (mean age = 31.2 ± 9.4; 31% female) to obtain averaged fractional anisotropy (FA) values of 18 white matter tracts. Statistical analyses examined correlations of FA values with blood-oxygenation-level-dependent (BOLD) response to an alcohol taste cue, measured with functional magnetic resonance imaging (fMRI). FA values of nine white matter tracts (anterior corona radiata, body of corpus callosum, cingulate gyrus, external capsule, fornix, inferior frontooccipital fasciculus, posterior corona radiata, retrolenticular limb of internal capsule, and superior longitudinal fasciculus) were significantly, negatively correlated with BOLD activation in medial frontal gyrus, parahippocampal gyrus, fusiform gyrus, cingulum, thalamus, caudate, putamen, insula, and cerebellum. The inverse relation between white matter integrity and functional activation during the alcohol taste cue provides support for the hypothesis that lower white matter integrity in frontoparietal and corticolimbic networks is a factor in loss of control over alcohol consumption. Wiley Periodicals, Inc. 2014-03 2013-12-29 /pmc/articles/PMC3967532/ /pubmed/24683509 http://dx.doi.org/10.1002/brb3.204 Text en © 2013 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Monnig, Mollie A
Thayer, Rachel E
Caprihan, Arvind
Claus, Eric D
Yeo, Ronald A
Calhoun, Vince D
Hutchison, Kent E
White matter integrity is associated with alcohol cue reactivity in heavy drinkers
title White matter integrity is associated with alcohol cue reactivity in heavy drinkers
title_full White matter integrity is associated with alcohol cue reactivity in heavy drinkers
title_fullStr White matter integrity is associated with alcohol cue reactivity in heavy drinkers
title_full_unstemmed White matter integrity is associated with alcohol cue reactivity in heavy drinkers
title_short White matter integrity is associated with alcohol cue reactivity in heavy drinkers
title_sort white matter integrity is associated with alcohol cue reactivity in heavy drinkers
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967532/
https://www.ncbi.nlm.nih.gov/pubmed/24683509
http://dx.doi.org/10.1002/brb3.204
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