Cargando…

Liquiritigenin Induces Tumor Cell Death through Mitogen-Activated Protein Kinase- (MPAKs-) Mediated Pathway in Hepatocellular Carcinoma Cells

Liquiritigenin (LQ), separated from Glycyrrhiza radix, possesses anti-inflammatory, antihyperlipidemic, and antiallergic effects. Our present study aims to investigate the antihepatocellular carcinoma effects of LQ both in cell and animal models. LQ strikingly reduced cell viability, enhanced apopto...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Di, Lu, Jiahui, Liu, Yan, Meng, Qingfan, Xie, Jing, Wang, Zhenzuo, Teng, Lesheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967596/ https://www.ncbi.nlm.nih.gov/pubmed/24738081 http://dx.doi.org/10.1155/2014/965316

Ejemplares similares

Liquiritin modulates ERK- and AKT/GSK-3β-dependent pathways to protect against glutamate-induced cell damage in differentiated PC12 cells
por: TENG, LESHENG, et al.
Publicado: (2014)

Involvement of the ERK pathway in the protective effects of glycyrrhizic acid against the MPP(+)-induced apoptosis of dopaminergic neuronal cells
por: TENG, LESHENG, et al.
Publicado: (2014)

Biotransformation of Liquiritigenin into Characteristic Metabolites by the Gut Microbiota
por: Keranmu, Adili, et al.
Publicado: (2022)

Liquiritigenin Inhibits Tumor Growth and Vascularization in a Mouse Model of Hela Cells
por: Liu, Yuxin, et al.
Publicado: (2012)

Stereospecific pharmacokinetic characterization of liquiritigenin in the rat
por: Alrushaid, Samaa, et al.
Publicado: (2017)

Cordyceps militaris induces tumor cell death via the caspase-dependent mitochondrial pathway in HepG2 and MCF-7 cells
por: SONG, JINGJING, et al.
Publicado: (2016)

Microfluidic hydrodynamic focusing synthesis of polymer-lipid nanoparticles for siRNA delivery
por: Huang, Xueqin, et al.
Publicado: (2017)

Pharmacological characterization of liquiritigenin, a chiral flavonoid in licorice
por: Alrushaid, Samaa, et al.
Publicado: (2016)

Liquiritigenin enhances cyclic adenosine monophosphate production to mitigate inflammation in dendritic cells
por: Qin, Mingming, et al.
Publicado: (2021)

Transferrin-conjugated liposomes loaded with novel dihydroquinoline derivatives as potential anticancer agents
por: Wang, Mengqiao, et al.
Publicado: (2017)

Curcumin activates the p38MPAK-HSP25 pathway in vitro but fails to attenuate diabetic nephropathy in DBA2J mice despite urinary clearance documented by HPLC
por: Ma, Jun, et al.
Publicado: (2010)

The Memory-Enhancing Effects of Liquiritigenin by Activation of NMDA Receptors and the CREB Signaling Pathway in Mice
por: Ko, Yong-Hyun, et al.
Publicado: (2018)

Liquiritin and Liquiritigenin Induce Melanogenesis via Enhancement of p38 and PKA Signaling Pathways
por: Uto, Takuhiro, et al.
Publicado: (2019)

Cabazitaxel-loaded human serum albumin nanoparticles as a therapeutic agent against prostate cancer
por: Qu, Na, et al.
Publicado: (2016)

Liquiritigenin Decreases Selective Molecular and Behavioral Effects of Cocaine in Rodents
por: Jang, E. Y, et al.
Publicado: (2011)

Spectroscopic and Docking Studies on the Binding of Liquiritigenin with Hyaluronidase for Antiallergic Mechanism
por: Zeng, Hua-jin, et al.
Publicado: (2016)

Reversing multidrug resistance in hepatocellular carcinoma cells by inhibiting extracellular signal-regulated kinase/mitogen-activated protein kinase signaling pathway activity
por: CHEN, SIYUAN, et al.
Publicado: (2014)

Hybrid micelles containing methotrexate-conjugated polymer and co-loaded with microRNA-124 for rheumatoid arthritis therapy
por: Hao, Fei, et al.
Publicado: (2019)

Medicago truncatula ABCG10 is a transporter of 4-coumarate and liquiritigenin in the medicarpin biosynthetic pathway
por: Biała, Wanda, et al.
Publicado: (2017)

Eupatorin-Induced Cell Death in Human Leukemia Cells Is Dependent on Caspases and Activates the Mitogen-Activated Protein Kinase Pathway
por: Estévez, Sara, et al.
Publicado: (2014)

Oral Administration of Liquiritigenin Confers Protection from Atopic Dermatitis through the Inhibition of T Cell Activation
por: Lee, Hyun-Su, et al.
Publicado: (2020)

The Calcium-Activated Chloride Channel TMEM16A is Inhibitied by Liquiritigenin
por: Kato, Mami, et al.
Publicado: (2021)

Near infrared spectroscopy coupled with radial basis function neural network for at-line monitoring of Lactococcus lactis subsp. fermentation
por: Liu, Yan, et al.
Publicado: (2016)

Tribbles pseudokinase 3 (TRIB3) contributes to the progression of hepatocellular carcinoma by activating the mitogen-activated protein kinase pathway
por: Wang, Rui-Qi, et al.
Publicado: (2021)

Liquiritigenin alleviates mechanical and cold hyperalgesia in a rat neuropathic pain model
por: Chen, Li, et al.
Publicado: (2014)

Liquiritigenin Protects Rats from Carbon Tetrachloride Induced Hepatic Injury through PGC-1α Pathway
por: Zhang, Yiping, et al.
Publicado: (2015)

Targeted Co-Delivery of siRNA and Methotrexate for Tumor Therapy via Mixed Micelles
por: Hao, Fei, et al.
Publicado: (2019)

Synthesis of Polymer-Lipid Nanoparticles by Microfluidic Focusing for siRNA Delivery
por: Li, Yujing, et al.
Publicado: (2016)

Insulin resistance enhances the mitogen-activated protein kinase signaling pathway in ovarian granulosa cells
por: Kong, Linghui, et al.
Publicado: (2017)

The Expression of Connexin 26 Regulates the Radiosensitivity of Hepatocellular Carcinoma Cells through a Mitogen-Activated Protein Kinases Signal Pathway
por: Li, Yuan, et al.
Publicado: (2022)

Effects of pentachlorophenol and tetrachlorohydroquinone on mitogen-activated protein kinase pathways in Jurkat T cells.
por: Wispriyono, Bambang, et al.
Publicado: (2002)

The Expanding Role of p38 Mitogen-Activated Protein Kinase in Programmed Host Cell Death
por: Gräb, Jessica, et al.
Publicado: (2019)

Xanthohumol induces paraptosis of leukemia cells through p38 mitogen activated protein kinase signaling pathway
por: Mi, Xiangquan, et al.
Publicado: (2017)

Mapping out the mitogen activated protein kinase pathway
por: Firestein, GS
Publicado: (2004)

Liquiritigenin Inhibits Lipid Accumulation in 3T3-L1 Cells via mTOR-Mediated Regulation of the Autophagy Mechanism
por: Qin, Hong, et al.
Publicado: (2022)

Liquiritigenin Reduces Blood Glucose Level and Bone Adverse Effects in Hyperglycemic Adult Zebrafish
por: Carnovali, Marta, et al.
Publicado: (2019)

Correction: Insulin resistance enhances the mitogen-activated protein kinase signaling pathway in ovarian granulosa cells
por: Kong, Linghui, et al.
Publicado: (2021)

Methionine Sulfoxide Reductase B1 Regulates Hepatocellular Carcinoma Cell Proliferation and Invasion via the Mitogen-Activated Protein Kinase Pathway and Epithelial-Mesenchymal Transition
por: He, Qiang, et al.
Publicado: (2018)

Mitogen- and Stress-Activated Protein Kinase 1 Regulates Status Epilepticus-Evoked Cell Death in the Hippocampus
por: Choi, Yun-Sik, et al.
Publicado: (2017)

Antitumor effect of resveratrol on chondrosarcoma cells via phosphoinositide 3-kinase/AKT and p38 mitogen-activated protein kinase pathways
por: Dai, Zixun, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_5ltc79vt9rps9utk9rb0dmmo0q