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An Evolutionary Analysis of Antigen Processing and Presentation across Different Timescales Reveals Pervasive Selection

The antigenic repertoire presented by MHC molecules is generated by the antigen processing and presentation (APP) pathway. We analyzed the evolutionary history of 45 genes involved in APP at the inter- and intra-species level. Results showed that 11 genes evolved adaptively in mammals. Several posit...

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Detalles Bibliográficos
Autores principales:	Forni, Diego, Cagliani, Rachele, Tresoldi, Claudia, Pozzoli, Uberto, De Gioia, Luca, Filippi, Giulia, Riva, Stefania, Menozzi, Giorgia, Colleoni, Marta, Biasin, Mara, Lo Caputo, Sergio, Mazzotta, Francesco, Comi, Giacomo P., Bresolin, Nereo, Clerici, Mario, Sironi, Manuela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967941/ https://www.ncbi.nlm.nih.gov/pubmed/24675550 http://dx.doi.org/10.1371/journal.pgen.1004189

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