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Extracellular Proteolysis of Apolipoprotein E (apoE) by Secreted Serine Neuronal Protease
Under normal conditions, brain apolipoprotein E (apoE) is secreted and lipidated by astrocytes, then taken up by neurons via receptor mediated endocytosis. Free apoE is either degraded in intraneuronal lysosomal compartments or released. Here we identified a novel way by which apoE undergoes proteol...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968057/ https://www.ncbi.nlm.nih.gov/pubmed/24675880 http://dx.doi.org/10.1371/journal.pone.0093120 |