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Mechanism of μ-Conotoxin PIIIA Binding to the Voltage-Gated Na(+) Channel Na(V)1.4
Several subtypes of voltage-gated Na(+) (Na(V)) channels are important targets for pain management. μ-Conotoxins isolated from venoms of cone snails are potent and specific blockers of different Na(V) channel isoforms. The inhibitory effect of μ-conotoxins on Na(V) channels has been examined extensi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968119/ https://www.ncbi.nlm.nih.gov/pubmed/24676211 http://dx.doi.org/10.1371/journal.pone.0093267 |