Interferon Regulatory Factor-1 Protects from Fatal Neurotropic Infection with Vesicular Stomatitis Virus by Specific Inhibition of Viral Replication in Neurons

The innate immune system protects cells against invading viral pathogens by the auto- and paracrine action of type I interferon (IFN). In addition, the interferon regulatory factor (IRF)-1 can induce alternative intrinsic antiviral responses. Although both, type I IFN and IRF-1 mediate their antivir...

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Detalles Bibliográficos
Autores principales: Nair, Sharmila, Michaelsen-Preusse, Kristin, Finsterbusch, Katja, Stegemann-Koniszewski, Sabine, Bruder, Dunja, Grashoff, Martina, Korte, Martin, Köster, Mario, Kalinke, Ulrich, Hauser, Hansjörg, Kröger, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968136/
https://www.ncbi.nlm.nih.gov/pubmed/24675692
http://dx.doi.org/10.1371/journal.ppat.1003999

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