Fasting plasma adropin concentrations correlate with fat consumption in human females

OBJECTIVE: This study investigated whether plasma adropin concentrations are influenced by sleep restriction and correlate with dietary preferences. DESIGN AND METHODS: Plasma adropin concentrations were measured by ELISA using samples from a study that investigated feeding behavior in sleep deprived lean (body mass index 22–26 kg/m(2)) men and women aged 30–45 y. Sleep (habitual or restricted to 4h/night) and diet were controlled during a 4-day inpatient period. On day 5, food was self-selected (FS). Adropin was measured on day 4 in samples collected throughout the day, and then after an overnight fast at 0730 on days 5 (Pre-FS) and 6 (Post-FS). RESULTS: Plasma adropin concentrations were not affected by sleep restriction. However, circulating adropin concentrations correlated with food selection preferences in women, irrespective of sleep status. Pre-FS adropin correlated positively with fat intake (total fat, r=0.867, P<0.05; saturated fat, r=0.959, P<0.01) and negatively with carbohydrate intake (r=−0.894, P<0.05) as a percent total energy. Post-FS adropin correlated with total (r=0.797, P<0.05) and saturated fat intake (r=0.945, P<0.01), and negative with total carbohydrate intake (r=−0.929, P<0.01). Pre-FS adropin also correlated with fat intake in kcal adjusted for body size (total fat, r=0.852, P<0.05; saturated fat, r=0.927, P<0.01). CONCLUSIONS: Plasma adropin concentrations correlate with fat consumption in women.