Investigation of Formulation and Process of Lyophilised Orally Disintegrating Tablet (ODT) Using Novel Amino Acid Combination

Lyophilised orally disintegrating tablets (ODTs) have achieved a great success in overcoming dysphagia associated with conventional solid dosage forms. However, the extensive use of saccharides within the formulation limits their use in treatment of chronic illnesses. The current study demonstrates...

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Autores principales: AlHusban, Farhan, ElShaer, Amr M., Kansara, Jiteen H., Smith, Alan M., Grover, Liam M., Perrie, Yvonne, Mohammed, Afzal R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968345/
https://www.ncbi.nlm.nih.gov/pubmed/27721339
http://dx.doi.org/10.3390/pharmaceutics2010001
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author AlHusban, Farhan
ElShaer, Amr M.
Kansara, Jiteen H.
Smith, Alan M.
Grover, Liam M.
Perrie, Yvonne
Mohammed, Afzal R.
author_facet AlHusban, Farhan
ElShaer, Amr M.
Kansara, Jiteen H.
Smith, Alan M.
Grover, Liam M.
Perrie, Yvonne
Mohammed, Afzal R.
author_sort AlHusban, Farhan
collection PubMed
description Lyophilised orally disintegrating tablets (ODTs) have achieved a great success in overcoming dysphagia associated with conventional solid dosage forms. However, the extensive use of saccharides within the formulation limits their use in treatment of chronic illnesses. The current study demonstrates the feasibility of using combination of proline and serine to formulate zero sacharide ODTs and investigates the effect of freezing protocol on sublimation rate and tablets characteristics. The results showed that inclusion of proline and serine improved ODT properties when compared to individual counterparts. Additionally, annealing the ODTs facilitated the sublimation process and shortened the disintegration time.
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spelling pubmed-39683452014-03-28 Investigation of Formulation and Process of Lyophilised Orally Disintegrating Tablet (ODT) Using Novel Amino Acid Combination AlHusban, Farhan ElShaer, Amr M. Kansara, Jiteen H. Smith, Alan M. Grover, Liam M. Perrie, Yvonne Mohammed, Afzal R. Pharmaceutics Article Lyophilised orally disintegrating tablets (ODTs) have achieved a great success in overcoming dysphagia associated with conventional solid dosage forms. However, the extensive use of saccharides within the formulation limits their use in treatment of chronic illnesses. The current study demonstrates the feasibility of using combination of proline and serine to formulate zero sacharide ODTs and investigates the effect of freezing protocol on sublimation rate and tablets characteristics. The results showed that inclusion of proline and serine improved ODT properties when compared to individual counterparts. Additionally, annealing the ODTs facilitated the sublimation process and shortened the disintegration time. Molecular Diversity Preservation International 2010-01-04 /pmc/articles/PMC3968345/ /pubmed/27721339 http://dx.doi.org/10.3390/pharmaceutics2010001 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
AlHusban, Farhan
ElShaer, Amr M.
Kansara, Jiteen H.
Smith, Alan M.
Grover, Liam M.
Perrie, Yvonne
Mohammed, Afzal R.
Investigation of Formulation and Process of Lyophilised Orally Disintegrating Tablet (ODT) Using Novel Amino Acid Combination
title Investigation of Formulation and Process of Lyophilised Orally Disintegrating Tablet (ODT) Using Novel Amino Acid Combination
title_full Investigation of Formulation and Process of Lyophilised Orally Disintegrating Tablet (ODT) Using Novel Amino Acid Combination
title_fullStr Investigation of Formulation and Process of Lyophilised Orally Disintegrating Tablet (ODT) Using Novel Amino Acid Combination
title_full_unstemmed Investigation of Formulation and Process of Lyophilised Orally Disintegrating Tablet (ODT) Using Novel Amino Acid Combination
title_short Investigation of Formulation and Process of Lyophilised Orally Disintegrating Tablet (ODT) Using Novel Amino Acid Combination
title_sort investigation of formulation and process of lyophilised orally disintegrating tablet (odt) using novel amino acid combination
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968345/
https://www.ncbi.nlm.nih.gov/pubmed/27721339
http://dx.doi.org/10.3390/pharmaceutics2010001
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