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Vitamin D and multiple sclerosis
Multiple sclerosis (MS) is a chronic demyelinating disease and also is one of the most common disabling neurological disorders in young and middle-aged adults. The main pathogenesis of MS has long been thought to be an immune mediated disorder of the central nervous system. The function of the immun...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tehran University of Medical Sciences
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968350/ https://www.ncbi.nlm.nih.gov/pubmed/24800040 |
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author | Harandi, Asghar Amini Harandi, Ali Amini Pakdaman, Hossein Sahraian, Mohammad Ali |
author_facet | Harandi, Asghar Amini Harandi, Ali Amini Pakdaman, Hossein Sahraian, Mohammad Ali |
author_sort | Harandi, Asghar Amini |
collection | PubMed |
description | Multiple sclerosis (MS) is a chronic demyelinating disease and also is one of the most common disabling neurological disorders in young and middle-aged adults. The main pathogenesis of MS has long been thought to be an immune mediated disorder of the central nervous system. The function of the immune system is under the influence of vitamin D which as a modulator of immune response could play a role in autoimmune diseases including MS. Deficiency of vitamin D or variations in DNA sequence (polymorphism) of vitamin D receptor gene diminishes its optimal function on immune system that consequently could lead to increasing risk of MS. However, its role in development and modulating the course of MS is still under investigation. In this review we aimed to discuss the role of vitamin D in body, immune system and consequently altering the risk of MS. |
format | Online Article Text |
id | pubmed-3968350 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Tehran University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-39683502014-05-05 Vitamin D and multiple sclerosis Harandi, Asghar Amini Harandi, Ali Amini Pakdaman, Hossein Sahraian, Mohammad Ali Iran J Neurol Review Article Multiple sclerosis (MS) is a chronic demyelinating disease and also is one of the most common disabling neurological disorders in young and middle-aged adults. The main pathogenesis of MS has long been thought to be an immune mediated disorder of the central nervous system. The function of the immune system is under the influence of vitamin D which as a modulator of immune response could play a role in autoimmune diseases including MS. Deficiency of vitamin D or variations in DNA sequence (polymorphism) of vitamin D receptor gene diminishes its optimal function on immune system that consequently could lead to increasing risk of MS. However, its role in development and modulating the course of MS is still under investigation. In this review we aimed to discuss the role of vitamin D in body, immune system and consequently altering the risk of MS. Tehran University of Medical Sciences 2014 /pmc/articles/PMC3968350/ /pubmed/24800040 Text en Copyright © 2014 Iranian Neurological Association, and Tehran University of Medical Sciences http://creativecommons.org/licenses/by/2.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly. |
spellingShingle | Review Article Harandi, Asghar Amini Harandi, Ali Amini Pakdaman, Hossein Sahraian, Mohammad Ali Vitamin D and multiple sclerosis |
title | Vitamin D and multiple sclerosis |
title_full | Vitamin D and multiple sclerosis |
title_fullStr | Vitamin D and multiple sclerosis |
title_full_unstemmed | Vitamin D and multiple sclerosis |
title_short | Vitamin D and multiple sclerosis |
title_sort | vitamin d and multiple sclerosis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968350/ https://www.ncbi.nlm.nih.gov/pubmed/24800040 |
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