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Increased expression of p62/SQSTM1 in prion diseases and its association with pathogenic prion protein

Prion diseases are neurodegenerative disorders characterized by the aggregation of abnormally folded prion protein (PrP(Sc)). In this study, we focused on the mechanism of clearance of PrP(Sc), which remains unclear. p62 is a cytosolic protein known to mediate both the formation and degradation of a...

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Detalles Bibliográficos
Autores principales:	Homma, Takujiro, Ishibashi, Daisuke, Nakagaki, Takehiro, Satoh, Katsuya, Sano, Kazunori, Atarashi, Ryuichiro, Nishida, Noriyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968452/ https://www.ncbi.nlm.nih.gov/pubmed/24675871 http://dx.doi.org/10.1038/srep04504

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