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Phosphoinositide-mediated oligomerization of a defensin induces cell lysis

Cationic antimicrobial peptides (CAPs) such as defensins are ubiquitously found innate immune molecules that often exhibit broad activity against microbial pathogens and mammalian tumor cells. Many CAPs act at the plasma membrane of cells leading to membrane destabilization and permeabilization. In...

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Detalles Bibliográficos
Autores principales:	Poon, Ivan KH, Baxter, Amy A, Lay, Fung T, Mills, Grant D, Adda, Christopher G, Payne, Jennifer AE, Phan, Thanh Kha, Ryan, Gemma F, White, Julie A, Veneer, Prem K, van der Weerden, Nicole L, Anderson, Marilyn A, Kvansakul, Marc, Hulett, Mark D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2014
Materias:	Biophysics and Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968744/ https://www.ncbi.nlm.nih.gov/pubmed/24692446 http://dx.doi.org/10.7554/eLife.01808

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