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The Active Site Sulfenic Acid Ligand in Nitrile Hydratases Can Function as a Nucleophile
[Image: see text] Nitrile hydratase (NHase) catalyzes the hydration of nitriles to their corresponding commercially valuable amides at ambient temperatures and physiological pH. Several reaction mechanisms have been proposed for NHase enzymes; however, the source of the nucleophile remains a mystery...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968781/ https://www.ncbi.nlm.nih.gov/pubmed/24383915 http://dx.doi.org/10.1021/ja410462j |