A case report of simultaneous PML-IRIS during corticosteroids tapering in a patient with an anti-synthetase syndrome

We report a case of simultaneous progressive multifocal leukoencephalopathy-associated immune reconstitution inflammatory syndrome (PML-IRIS) during corticosteroid tapering in a patient with an anti-synthetase syndrome. We describe the challenges associated with the diagnosis and the management of t...

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Detalles Bibliográficos
Autores principales: Martin-Blondel, Guillaume, Brassat, David, Dumas, Hervé, Uro-Coste, Emmanuelle, Adoue, Daniel, Lassmann, Hans, Clanet, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968897/
https://www.ncbi.nlm.nih.gov/pubmed/24715969
http://dx.doi.org/10.12688/f1000research.2-283.v1
Descripción
Sumario:We report a case of simultaneous progressive multifocal leukoencephalopathy-associated immune reconstitution inflammatory syndrome (PML-IRIS) during corticosteroid tapering in a patient with an anti-synthetase syndrome. We describe the challenges associated with the diagnosis and the management of this emerging inflammatory neurological condition in this immunocompromised patient with a severe rheumatic disease. We highlight that, in the setting of IRIS, the low-level of the JC virus viral load requires a sensitive PCR assay before excluding PML.

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