A case report of simultaneous PML-IRIS during corticosteroids tapering in a patient with an anti-synthetase syndrome

We report a case of simultaneous progressive multifocal leukoencephalopathy-associated immune reconstitution inflammatory syndrome (PML-IRIS) during corticosteroid tapering in a patient with an anti-synthetase syndrome. We describe the challenges associated with the diagnosis and the management of t...

Descripción completa

Detalles Bibliográficos
Autores principales: Martin-Blondel, Guillaume, Brassat, David, Dumas, Hervé, Uro-Coste, Emmanuelle, Adoue, Daniel, Lassmann, Hans, Clanet, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968897/
https://www.ncbi.nlm.nih.gov/pubmed/24715969
http://dx.doi.org/10.12688/f1000research.2-283.v1
_version_ 1782309213847945216
author Martin-Blondel, Guillaume
Brassat, David
Dumas, Hervé
Uro-Coste, Emmanuelle
Adoue, Daniel
Lassmann, Hans
Clanet, Michel
author_facet Martin-Blondel, Guillaume
Brassat, David
Dumas, Hervé
Uro-Coste, Emmanuelle
Adoue, Daniel
Lassmann, Hans
Clanet, Michel
author_sort Martin-Blondel, Guillaume
collection PubMed
description We report a case of simultaneous progressive multifocal leukoencephalopathy-associated immune reconstitution inflammatory syndrome (PML-IRIS) during corticosteroid tapering in a patient with an anti-synthetase syndrome. We describe the challenges associated with the diagnosis and the management of this emerging inflammatory neurological condition in this immunocompromised patient with a severe rheumatic disease. We highlight that, in the setting of IRIS, the low-level of the JC virus viral load requires a sensitive PCR assay before excluding PML.
format Online
Article
Text
id pubmed-3968897
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher F1000Research
record_format MEDLINE/PubMed
spelling pubmed-39688972014-04-07 A case report of simultaneous PML-IRIS during corticosteroids tapering in a patient with an anti-synthetase syndrome Martin-Blondel, Guillaume Brassat, David Dumas, Hervé Uro-Coste, Emmanuelle Adoue, Daniel Lassmann, Hans Clanet, Michel F1000Res Case Report We report a case of simultaneous progressive multifocal leukoencephalopathy-associated immune reconstitution inflammatory syndrome (PML-IRIS) during corticosteroid tapering in a patient with an anti-synthetase syndrome. We describe the challenges associated with the diagnosis and the management of this emerging inflammatory neurological condition in this immunocompromised patient with a severe rheumatic disease. We highlight that, in the setting of IRIS, the low-level of the JC virus viral load requires a sensitive PCR assay before excluding PML. F1000Research 2013-12-23 /pmc/articles/PMC3968897/ /pubmed/24715969 http://dx.doi.org/10.12688/f1000research.2-283.v1 Text en Copyright: © 2013 Martin-Blondel G et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/publicdomain/zero/1.0/ Data associated with the article are available under the terms of the Creative Commons Zero "No rights reserved" data waiver (CC0 1.0 Public domain dedication).
spellingShingle Case Report
Martin-Blondel, Guillaume
Brassat, David
Dumas, Hervé
Uro-Coste, Emmanuelle
Adoue, Daniel
Lassmann, Hans
Clanet, Michel
A case report of simultaneous PML-IRIS during corticosteroids tapering in a patient with an anti-synthetase syndrome
title A case report of simultaneous PML-IRIS during corticosteroids tapering in a patient with an anti-synthetase syndrome
title_full A case report of simultaneous PML-IRIS during corticosteroids tapering in a patient with an anti-synthetase syndrome
title_fullStr A case report of simultaneous PML-IRIS during corticosteroids tapering in a patient with an anti-synthetase syndrome
title_full_unstemmed A case report of simultaneous PML-IRIS during corticosteroids tapering in a patient with an anti-synthetase syndrome
title_short A case report of simultaneous PML-IRIS during corticosteroids tapering in a patient with an anti-synthetase syndrome
title_sort case report of simultaneous pml-iris during corticosteroids tapering in a patient with an anti-synthetase syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968897/
https://www.ncbi.nlm.nih.gov/pubmed/24715969
http://dx.doi.org/10.12688/f1000research.2-283.v1
work_keys_str_mv AT martinblondelguillaume acasereportofsimultaneouspmlirisduringcorticosteroidstaperinginapatientwithanantisynthetasesyndrome
AT brassatdavid acasereportofsimultaneouspmlirisduringcorticosteroidstaperinginapatientwithanantisynthetasesyndrome
AT dumasherve acasereportofsimultaneouspmlirisduringcorticosteroidstaperinginapatientwithanantisynthetasesyndrome
AT urocosteemmanuelle acasereportofsimultaneouspmlirisduringcorticosteroidstaperinginapatientwithanantisynthetasesyndrome
AT adouedaniel acasereportofsimultaneouspmlirisduringcorticosteroidstaperinginapatientwithanantisynthetasesyndrome
AT lassmannhans acasereportofsimultaneouspmlirisduringcorticosteroidstaperinginapatientwithanantisynthetasesyndrome
AT clanetmichel acasereportofsimultaneouspmlirisduringcorticosteroidstaperinginapatientwithanantisynthetasesyndrome
AT martinblondelguillaume casereportofsimultaneouspmlirisduringcorticosteroidstaperinginapatientwithanantisynthetasesyndrome
AT brassatdavid casereportofsimultaneouspmlirisduringcorticosteroidstaperinginapatientwithanantisynthetasesyndrome
AT dumasherve casereportofsimultaneouspmlirisduringcorticosteroidstaperinginapatientwithanantisynthetasesyndrome
AT urocosteemmanuelle casereportofsimultaneouspmlirisduringcorticosteroidstaperinginapatientwithanantisynthetasesyndrome
AT adouedaniel casereportofsimultaneouspmlirisduringcorticosteroidstaperinginapatientwithanantisynthetasesyndrome
AT lassmannhans casereportofsimultaneouspmlirisduringcorticosteroidstaperinginapatientwithanantisynthetasesyndrome
AT clanetmichel casereportofsimultaneouspmlirisduringcorticosteroidstaperinginapatientwithanantisynthetasesyndrome

Ejemplares similares