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Cancer quasispecies and stem-like adaptive aneuploidy

In this paper we develop a theoretical frame to understand self-regulation of aneuploidy rate in cancer and stem cells. This is accomplished building upon quasispecies theory, by leaving its formal mathematical structure intact, but by drastically changing the meaning of its objects. In particular,...

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Autores principales: Napoletani, Domenico, Signore, Michele, Struppa, Daniele C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968898/
https://www.ncbi.nlm.nih.gov/pubmed/24715964
http://dx.doi.org/10.12688/f1000research.2-268.v1
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author Napoletani, Domenico
Signore, Michele
Struppa, Daniele C
author_facet Napoletani, Domenico
Signore, Michele
Struppa, Daniele C
author_sort Napoletani, Domenico
collection PubMed
description In this paper we develop a theoretical frame to understand self-regulation of aneuploidy rate in cancer and stem cells. This is accomplished building upon quasispecies theory, by leaving its formal mathematical structure intact, but by drastically changing the meaning of its objects. In particular, we propose a novel definition of chromosomal master sequence, as a sequence of physically distinct whole or fragmented chromosomes, whose length is taken to be the sum of the copy numbers of each whole or fragmented chromosome. This fundamental change in the functional objects of quasispecies theory allows us to show that previously measured aneuploidy rates in cancer populations are already close to a formally derived aneuploid error threshold, and that any value of aneuploidy rate larger than the aneuploid error threshold would lead to a loss of fitness of a tumor population. Finally, we make a phenomenological analysis of existing experimental evidence to argue that single clone cancer cells, derived from an aneuploid cancer subpopulation, are capable of self-regulating their aneuploidy rate and of adapting it to distinct environments, namely primary and metastatic microenvironments. We also discuss the potential origin of this self-regulatory ability in the wider context of developmental and comparative biology and we hypothesize the existence of a diversification factor, i.e. a cellular mechanism that regulates adaptation of aneuploidy rates, active in all embryo, adult and cancer stem cells.
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spelling pubmed-39688982014-04-07 Cancer quasispecies and stem-like adaptive aneuploidy Napoletani, Domenico Signore, Michele Struppa, Daniele C F1000Res Opinion Article In this paper we develop a theoretical frame to understand self-regulation of aneuploidy rate in cancer and stem cells. This is accomplished building upon quasispecies theory, by leaving its formal mathematical structure intact, but by drastically changing the meaning of its objects. In particular, we propose a novel definition of chromosomal master sequence, as a sequence of physically distinct whole or fragmented chromosomes, whose length is taken to be the sum of the copy numbers of each whole or fragmented chromosome. This fundamental change in the functional objects of quasispecies theory allows us to show that previously measured aneuploidy rates in cancer populations are already close to a formally derived aneuploid error threshold, and that any value of aneuploidy rate larger than the aneuploid error threshold would lead to a loss of fitness of a tumor population. Finally, we make a phenomenological analysis of existing experimental evidence to argue that single clone cancer cells, derived from an aneuploid cancer subpopulation, are capable of self-regulating their aneuploidy rate and of adapting it to distinct environments, namely primary and metastatic microenvironments. We also discuss the potential origin of this self-regulatory ability in the wider context of developmental and comparative biology and we hypothesize the existence of a diversification factor, i.e. a cellular mechanism that regulates adaptation of aneuploidy rates, active in all embryo, adult and cancer stem cells. F1000Research 2013-12-06 /pmc/articles/PMC3968898/ /pubmed/24715964 http://dx.doi.org/10.12688/f1000research.2-268.v1 Text en Copyright: © 2013 Napoletani D et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Opinion Article
Napoletani, Domenico
Signore, Michele
Struppa, Daniele C
Cancer quasispecies and stem-like adaptive aneuploidy
title Cancer quasispecies and stem-like adaptive aneuploidy
title_full Cancer quasispecies and stem-like adaptive aneuploidy
title_fullStr Cancer quasispecies and stem-like adaptive aneuploidy
title_full_unstemmed Cancer quasispecies and stem-like adaptive aneuploidy
title_short Cancer quasispecies and stem-like adaptive aneuploidy
title_sort cancer quasispecies and stem-like adaptive aneuploidy
topic Opinion Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968898/
https://www.ncbi.nlm.nih.gov/pubmed/24715964
http://dx.doi.org/10.12688/f1000research.2-268.v1
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