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Dysregulation of glucose metabolism is an early event in sporadic Parkinson's disease()

Unlike most other cell types, neurons preferentially metabolize glucose via the pentose phosphate pathway (PPP) to maintain their antioxidant status. Inhibiting the PPP in neuronal cell models causes cell death. In rodents, inhibition of this pathway causes selective dopaminergic cell death leading...

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Detalles Bibliográficos
Autores principales:	Dunn, Laura, Allen, George FG., Mamais, Adamantios, Ling, Helen, Li, Abi, Duberley, Kate E., Hargreaves, Iain P., Pope, Simon, Holton, Janice L., Lees, Andrew, Heales, Simon J., Bandopadhyay, Rina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2014
Materias:	Brief Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969149/ https://www.ncbi.nlm.nih.gov/pubmed/24300239 http://dx.doi.org/10.1016/j.neurobiolaging.2013.11.001

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