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Transport of estradiol-17β-glucuronide, estrone-3-sulfate and taurocholate across the endoplasmic reticulum membrane: evidence for different transport systems()

Important reactions of drug metabolism, including UGT mediated glucuronidation and steroidsulfatase mediated hydrolysis of sulfates, take place in the endoplasmic reticulum (ER) of hepatocytes. Consequently, UGT generated glucuronides, like estradiol-17β-glucuronide, have to be translocated back int...

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Detalles Bibliográficos
Autores principales:	Wlcek, Katrin, Hofstetter, Lia, Stieger, Bruno
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969151/ https://www.ncbi.nlm.nih.gov/pubmed/24406246 http://dx.doi.org/10.1016/j.bcp.2013.12.026

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