Cargando…
Pain without Nociceptors? Nav1.7-Independent Pain Mechanisms
Nav1.7, a peripheral neuron voltage-gated sodium channel, is essential for pain and olfaction in mice and humans. We examined the role of Nav1.7 as well as Nav1.3, Nav1.8, and Nav1.9 in different mouse models of chronic pain. Constriction-injury-dependent neuropathic pain is abolished when Nav1.7 is...
Autores principales: | Minett, Michael S., Falk, Sarah, Santana-Varela, Sonia, Bogdanov, Yury D., Nassar, Mohammed A., Heegaard, Anne-Marie, Wood, John N. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969273/ https://www.ncbi.nlm.nih.gov/pubmed/24440715 http://dx.doi.org/10.1016/j.celrep.2013.12.033 |
Ejemplares similares
-
Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons
por: Minett, Michael S., et al.
Publicado: (2012) -
Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Na(v)1.7
por: Minett, Michael S., et al.
Publicado: (2015) -
Nociceptor-expressed ephrin-B2 regulates inflammatory and neuropathic pain
por: Zhao, Jing, et al.
Publicado: (2010) -
Hydropathicity-based prediction of pain-causing NaV1.7 variants
por: Xenakis, Makros N., et al.
Publicado: (2021) -
Inhibition of the Nav1.7 Channel in the Trigeminal Ganglion Relieves Pulpitis Inflammatory Pain
por: Kwon, Minjee, et al.
Publicado: (2021)