MDL-1, a growth- and tumor-suppressor, slows aging and prevents germline hyperplasia and hypertrophy in C. elegans

In C. elegans, increased lifespan in daf-2 insulin/IGF-1 receptor mutants is accompanied by up-regulation of the MDL-1 Mad basic helix-loop-helix leucine zipper transcription factor. Here we describe the role of mdl-1 in C. elegans germline proliferation and aging. The deletion allele mdl-1(tm311) s...

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Detalles Bibliográficos
Autores principales: Riesen, Michèle, Feyst, Inna, Rattanavirotkul, Nattaphong, Ezcurra, Marina, Tullet, Jennifer M.A., Papatheodorou, Irene, Ziehm, Matthias, Au, Catherine, Gilliat, Ann F., Hellberg, Josephine, Thornton, Janet M., Gems, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969279/
https://www.ncbi.nlm.nih.gov/pubmed/24531613

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