Structural organisation of the type IV secretion systems()

Type IV secretion (T4S) systems are large dynamic nanomachines that transport DNAs and/or proteins through the membranes of bacteria. Because of their complexity and multi-protein organisation, T4S systems have been extremely challenging to study structurally. However in the past five years signific...

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Detalles Bibliográficos
Autores principales: Waksman, Gabriel, Orlova, Elena V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Current Biology 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969286/
https://www.ncbi.nlm.nih.gov/pubmed/24581689
http://dx.doi.org/10.1016/j.mib.2013.11.001
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author Waksman, Gabriel
Orlova, Elena V
author_facet Waksman, Gabriel
Orlova, Elena V
author_sort Waksman, Gabriel
collection PubMed
description Type IV secretion (T4S) systems are large dynamic nanomachines that transport DNAs and/or proteins through the membranes of bacteria. Because of their complexity and multi-protein organisation, T4S systems have been extremely challenging to study structurally. However in the past five years significant milestones have been achieved by X-ray crystallography and cryo-electron microscopy. This review describes some of the more recent advances: the structures of some of the protein components of the T4S systems and the complete core complex structure that was determined using electron microscopy.
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spelling pubmed-39692862014-03-31 Structural organisation of the type IV secretion systems() Waksman, Gabriel Orlova, Elena V Curr Opin Microbiol Article Type IV secretion (T4S) systems are large dynamic nanomachines that transport DNAs and/or proteins through the membranes of bacteria. Because of their complexity and multi-protein organisation, T4S systems have been extremely challenging to study structurally. However in the past five years significant milestones have been achieved by X-ray crystallography and cryo-electron microscopy. This review describes some of the more recent advances: the structures of some of the protein components of the T4S systems and the complete core complex structure that was determined using electron microscopy. Current Biology 2014-02 /pmc/articles/PMC3969286/ /pubmed/24581689 http://dx.doi.org/10.1016/j.mib.2013.11.001 Text en © 2013 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Waksman, Gabriel
Orlova, Elena V
Structural organisation of the type IV secretion systems()
title Structural organisation of the type IV secretion systems()
title_full Structural organisation of the type IV secretion systems()
title_fullStr Structural organisation of the type IV secretion systems()
title_full_unstemmed Structural organisation of the type IV secretion systems()
title_short Structural organisation of the type IV secretion systems()
title_sort structural organisation of the type iv secretion systems()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969286/
https://www.ncbi.nlm.nih.gov/pubmed/24581689
http://dx.doi.org/10.1016/j.mib.2013.11.001
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