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Role of gamma carboxylated Glu47 in connexin 26 hemichannel regulation by extracellular Ca(2+): Insight from a local quantum chemistry study
Connexin hemichannels are regulated by several gating mechanisms, some of which depend critically on the extracellular Ca(2+) concentration ([Ca(2+)](e)). It is well established that hemichannel activity is inhibited at normal (∼1 mM) [Ca(2+)](e), whereas lowering [Ca(2+)](e) to micromolar levels fo...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Academic Press
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969289/ https://www.ncbi.nlm.nih.gov/pubmed/24468086 http://dx.doi.org/10.1016/j.bbrc.2014.01.063 |