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A Long QT Mutation Substitutes Cholesterol for Phosphatidylinositol-4,5-Bisphosphate in KCNQ1 Channel Regulation

INTRODUCTION: Phosphatidylinositol-4,5-bisphosphate (PIP(2)) is a cofactor necessary for the activity of KCNQ1 channels. Some Long QT mutations of KCNQ1, including R243H, R539W and R555C have been shown to decrease KCNQ1 interaction with PIP(2). A previous study suggested that R539W is paradoxically...

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Detalles Bibliográficos
Autores principales:	Coyan, Fabien C., Abderemane-Ali, Fayal, Amarouch, Mohamed Yassine, Piron, Julien, Mordel, Jérôme, Nicolas, Céline S., Steenman, Marja, Mérot, Jean, Marionneau, Céline, Thomas, Annick, Brasseur, Robert, Baró, Isabelle, Loussouarn, Gildas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969324/ https://www.ncbi.nlm.nih.gov/pubmed/24681627 http://dx.doi.org/10.1371/journal.pone.0093255

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