Venturicidin C, A New 20-Membered Macrolide Produced by Streptomyces sp. TS-2-2

Venturicidin C (1), a new 20-membered macrolide along with the known venturicidins A (2) and B (3) were isolated from the crude extract of the Appalachian bacterial strain Streptomyces sp. TS-2-2. Additionally, nine other known compounds namely nocardamine, dehydroxynocardamine, desmethylenlnocardam...

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Detalles Bibliográficos
Autores principales: Shaaban, Khaled A., Singh, Shanteri, Elshahawi, Sherif I., Wang, Xiachang, Ponomareva, Larissa V., Sunkara, Manjula, Copley, Gregory C., Hower, James C., Morris, Andrew J., Kharel, Madan K., Thorson, Jon S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969387/
https://www.ncbi.nlm.nih.gov/pubmed/24252813
http://dx.doi.org/10.1038/ja.2013.113
Descripción
Sumario:Venturicidin C (1), a new 20-membered macrolide along with the known venturicidins A (2) and B (3) were isolated from the crude extract of the Appalachian bacterial strain Streptomyces sp. TS-2-2. Additionally, nine other known compounds namely nocardamine, dehydroxynocardamine, desmethylenlnocardamine, ferrioxamine E (FOE), adenosine, riboflavin, cyclo(d)-trans-4-OH-Pro-(d)-Phe, cyclo(d)-Pro-(d)-Phe, and N-(2-phenylethyl)-acetamide were also isolated and identified. The structure of the new macrolide 1 was elucidated by the cumulative analyses of NMR and HR-MS spectrometry data. Complete NMR assignments for the known venturicidins A (2) and B (3) are also provided, for the first time, in this report. Venturicidins A-C did not inhibit the proliferation of A549 lung cancer cell lines but all displayed potent antifungal activity.

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