Venturicidin C, A New 20-Membered Macrolide Produced by Streptomyces sp. TS-2-2

Venturicidin C (1), a new 20-membered macrolide along with the known venturicidins A (2) and B (3) were isolated from the crude extract of the Appalachian bacterial strain Streptomyces sp. TS-2-2. Additionally, nine other known compounds namely nocardamine, dehydroxynocardamine, desmethylenlnocardam...

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Autores principales: Shaaban, Khaled A., Singh, Shanteri, Elshahawi, Sherif I., Wang, Xiachang, Ponomareva, Larissa V., Sunkara, Manjula, Copley, Gregory C., Hower, James C., Morris, Andrew J., Kharel, Madan K., Thorson, Jon S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969387/
https://www.ncbi.nlm.nih.gov/pubmed/24252813
http://dx.doi.org/10.1038/ja.2013.113
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author Shaaban, Khaled A.
Singh, Shanteri
Elshahawi, Sherif I.
Wang, Xiachang
Ponomareva, Larissa V.
Sunkara, Manjula
Copley, Gregory C.
Hower, James C.
Morris, Andrew J.
Kharel, Madan K.
Thorson, Jon S.
author_facet Shaaban, Khaled A.
Singh, Shanteri
Elshahawi, Sherif I.
Wang, Xiachang
Ponomareva, Larissa V.
Sunkara, Manjula
Copley, Gregory C.
Hower, James C.
Morris, Andrew J.
Kharel, Madan K.
Thorson, Jon S.
author_sort Shaaban, Khaled A.
collection PubMed
description Venturicidin C (1), a new 20-membered macrolide along with the known venturicidins A (2) and B (3) were isolated from the crude extract of the Appalachian bacterial strain Streptomyces sp. TS-2-2. Additionally, nine other known compounds namely nocardamine, dehydroxynocardamine, desmethylenlnocardamine, ferrioxamine E (FOE), adenosine, riboflavin, cyclo(d)-trans-4-OH-Pro-(d)-Phe, cyclo(d)-Pro-(d)-Phe, and N-(2-phenylethyl)-acetamide were also isolated and identified. The structure of the new macrolide 1 was elucidated by the cumulative analyses of NMR and HR-MS spectrometry data. Complete NMR assignments for the known venturicidins A (2) and B (3) are also provided, for the first time, in this report. Venturicidins A-C did not inhibit the proliferation of A549 lung cancer cell lines but all displayed potent antifungal activity.
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spelling pubmed-39693872014-09-01 Venturicidin C, A New 20-Membered Macrolide Produced by Streptomyces sp. TS-2-2 Shaaban, Khaled A. Singh, Shanteri Elshahawi, Sherif I. Wang, Xiachang Ponomareva, Larissa V. Sunkara, Manjula Copley, Gregory C. Hower, James C. Morris, Andrew J. Kharel, Madan K. Thorson, Jon S. J Antibiot (Tokyo) Article Venturicidin C (1), a new 20-membered macrolide along with the known venturicidins A (2) and B (3) were isolated from the crude extract of the Appalachian bacterial strain Streptomyces sp. TS-2-2. Additionally, nine other known compounds namely nocardamine, dehydroxynocardamine, desmethylenlnocardamine, ferrioxamine E (FOE), adenosine, riboflavin, cyclo(d)-trans-4-OH-Pro-(d)-Phe, cyclo(d)-Pro-(d)-Phe, and N-(2-phenylethyl)-acetamide were also isolated and identified. The structure of the new macrolide 1 was elucidated by the cumulative analyses of NMR and HR-MS spectrometry data. Complete NMR assignments for the known venturicidins A (2) and B (3) are also provided, for the first time, in this report. Venturicidins A-C did not inhibit the proliferation of A549 lung cancer cell lines but all displayed potent antifungal activity. 2013-11-13 2014-03 /pmc/articles/PMC3969387/ /pubmed/24252813 http://dx.doi.org/10.1038/ja.2013.113 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Shaaban, Khaled A.
Singh, Shanteri
Elshahawi, Sherif I.
Wang, Xiachang
Ponomareva, Larissa V.
Sunkara, Manjula
Copley, Gregory C.
Hower, James C.
Morris, Andrew J.
Kharel, Madan K.
Thorson, Jon S.
Venturicidin C, A New 20-Membered Macrolide Produced by Streptomyces sp. TS-2-2
title Venturicidin C, A New 20-Membered Macrolide Produced by Streptomyces sp. TS-2-2
title_full Venturicidin C, A New 20-Membered Macrolide Produced by Streptomyces sp. TS-2-2
title_fullStr Venturicidin C, A New 20-Membered Macrolide Produced by Streptomyces sp. TS-2-2
title_full_unstemmed Venturicidin C, A New 20-Membered Macrolide Produced by Streptomyces sp. TS-2-2
title_short Venturicidin C, A New 20-Membered Macrolide Produced by Streptomyces sp. TS-2-2
title_sort venturicidin c, a new 20-membered macrolide produced by streptomyces sp. ts-2-2
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969387/
https://www.ncbi.nlm.nih.gov/pubmed/24252813
http://dx.doi.org/10.1038/ja.2013.113
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