A review of preclinical animal models utilised for TB vaccine evaluation in the context of recent human efficacy data()

There is an urgent need for an improved TB vaccine. Vaccine development is hindered by the lack of immune correlates and uncertain predictive value of preclinical animal models. As data become available from human efficacy trials, there is an opportunity to evaluate the predictive value of the crite...

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Detalles Bibliográficos
Autores principales: McShane, Helen, Williams, Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Churchill Livingstone 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969587/
https://www.ncbi.nlm.nih.gov/pubmed/24369986
http://dx.doi.org/10.1016/j.tube.2013.11.003
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author McShane, Helen
Williams, Ann
author_facet McShane, Helen
Williams, Ann
author_sort McShane, Helen
collection PubMed
description There is an urgent need for an improved TB vaccine. Vaccine development is hindered by the lack of immune correlates and uncertain predictive value of preclinical animal models. As data become available from human efficacy trials, there is an opportunity to evaluate the predictive value of the criteria used to select candidate vaccines. Here we review the efficacy in animal models of the MVA85A candidate vaccine in light of recent human efficacy data and propose refinements to the preclinical models with the aim of increasing their predictive value for human efficacy.
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spelling pubmed-39695872014-03-31 A review of preclinical animal models utilised for TB vaccine evaluation in the context of recent human efficacy data() McShane, Helen Williams, Ann Tuberculosis (Edinb) Review There is an urgent need for an improved TB vaccine. Vaccine development is hindered by the lack of immune correlates and uncertain predictive value of preclinical animal models. As data become available from human efficacy trials, there is an opportunity to evaluate the predictive value of the criteria used to select candidate vaccines. Here we review the efficacy in animal models of the MVA85A candidate vaccine in light of recent human efficacy data and propose refinements to the preclinical models with the aim of increasing their predictive value for human efficacy. Churchill Livingstone 2014-03 /pmc/articles/PMC3969587/ /pubmed/24369986 http://dx.doi.org/10.1016/j.tube.2013.11.003 Text en © 2013 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
McShane, Helen
Williams, Ann
A review of preclinical animal models utilised for TB vaccine evaluation in the context of recent human efficacy data()
title A review of preclinical animal models utilised for TB vaccine evaluation in the context of recent human efficacy data()
title_full A review of preclinical animal models utilised for TB vaccine evaluation in the context of recent human efficacy data()
title_fullStr A review of preclinical animal models utilised for TB vaccine evaluation in the context of recent human efficacy data()
title_full_unstemmed A review of preclinical animal models utilised for TB vaccine evaluation in the context of recent human efficacy data()
title_short A review of preclinical animal models utilised for TB vaccine evaluation in the context of recent human efficacy data()
title_sort review of preclinical animal models utilised for tb vaccine evaluation in the context of recent human efficacy data()
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969587/
https://www.ncbi.nlm.nih.gov/pubmed/24369986
http://dx.doi.org/10.1016/j.tube.2013.11.003
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