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Aliphatic and eudesmalolide esters extracted from the roots of Inula racemosa Hook
BACKGROUND: Phytochemical investigation of hydroalcoholic extract of the root of Inula racemosa Hook. MATERIALS AND METHODS: Open silica gel column chromatographic techniques with different solvent systems was used for isolation of aliphatic and eudesmalolide esters from hydroalcoholic extract of th...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969657/ https://www.ncbi.nlm.nih.gov/pubmed/24695458 http://dx.doi.org/10.4103/0973-1296.126657 |
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author | Khan, Maria Mir, S.R. Ali, Abuzar Yusuf, Mohammad Ali, Mohammed |
author_facet | Khan, Maria Mir, S.R. Ali, Abuzar Yusuf, Mohammad Ali, Mohammed |
author_sort | Khan, Maria |
collection | PubMed |
description | BACKGROUND: Phytochemical investigation of hydroalcoholic extract of the root of Inula racemosa Hook. MATERIALS AND METHODS: Open silica gel column chromatographic techniques with different solvent systems was used for isolation of aliphatic and eudesmalolide esters from hydroalcoholic extract of the root of Inula racemosa. The structure elucidation of the compounds was done on the basis of spectral data analysis, chemical reactions and comparision with literature data. RESULTS: Phytochemical investigation of the hydroalcoholic extract of the root of Inula racemosa Hook. f. led to the isolation of (5z, 13z)-n-decanyl-n-docos-5, 13-dienoate, a new fatty acid ester, two new sesquiterpenic ester identified as 15-[(13z, 18′z, 20′z)-n-tricos-13, 18, 20-trienyl]-eudesmal-4 (11), 6, 12 (13)-trien-8,14-olide-15-oate and 15- [(16′z), (21′z)-n- tetracos-16′, 21′- dienyl]-eudesmal-4 (11) 6, 12 (13)-trien-8, 14-olide-15-oate, two new eudesmanolide ester i.e. 15-[(16z)-n-monadec-16′- enyl]-eudesmal-4 (11) 6, 12 (13)-trien-8,14-olide-15-oate and 15-[(16′z)-n-tetracos-16′- enyl]-endesmal-4 (11), 6, 12 (13)-trien-8,14-olide-15-oate along with the known compound n-Hexadecanyl n-docosanoate. CONCLUSION: Five new phytoconstituents were identified along with one known compound as aliphatic and eudesmalolide esters from the hydroalcoholic extract of the root of Inula racemosa, as mentioned above. |
format | Online Article Text |
id | pubmed-3969657 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-39696572014-04-02 Aliphatic and eudesmalolide esters extracted from the roots of Inula racemosa Hook Khan, Maria Mir, S.R. Ali, Abuzar Yusuf, Mohammad Ali, Mohammed Pharmacogn Mag Original Article BACKGROUND: Phytochemical investigation of hydroalcoholic extract of the root of Inula racemosa Hook. MATERIALS AND METHODS: Open silica gel column chromatographic techniques with different solvent systems was used for isolation of aliphatic and eudesmalolide esters from hydroalcoholic extract of the root of Inula racemosa. The structure elucidation of the compounds was done on the basis of spectral data analysis, chemical reactions and comparision with literature data. RESULTS: Phytochemical investigation of the hydroalcoholic extract of the root of Inula racemosa Hook. f. led to the isolation of (5z, 13z)-n-decanyl-n-docos-5, 13-dienoate, a new fatty acid ester, two new sesquiterpenic ester identified as 15-[(13z, 18′z, 20′z)-n-tricos-13, 18, 20-trienyl]-eudesmal-4 (11), 6, 12 (13)-trien-8,14-olide-15-oate and 15- [(16′z), (21′z)-n- tetracos-16′, 21′- dienyl]-eudesmal-4 (11) 6, 12 (13)-trien-8, 14-olide-15-oate, two new eudesmanolide ester i.e. 15-[(16z)-n-monadec-16′- enyl]-eudesmal-4 (11) 6, 12 (13)-trien-8,14-olide-15-oate and 15-[(16′z)-n-tetracos-16′- enyl]-endesmal-4 (11), 6, 12 (13)-trien-8,14-olide-15-oate along with the known compound n-Hexadecanyl n-docosanoate. CONCLUSION: Five new phytoconstituents were identified along with one known compound as aliphatic and eudesmalolide esters from the hydroalcoholic extract of the root of Inula racemosa, as mentioned above. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC3969657/ /pubmed/24695458 http://dx.doi.org/10.4103/0973-1296.126657 Text en Copyright: © Pharmacognosy Magazine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Khan, Maria Mir, S.R. Ali, Abuzar Yusuf, Mohammad Ali, Mohammed Aliphatic and eudesmalolide esters extracted from the roots of Inula racemosa Hook |
title | Aliphatic and eudesmalolide esters extracted from the roots of Inula racemosa Hook |
title_full | Aliphatic and eudesmalolide esters extracted from the roots of Inula racemosa Hook |
title_fullStr | Aliphatic and eudesmalolide esters extracted from the roots of Inula racemosa Hook |
title_full_unstemmed | Aliphatic and eudesmalolide esters extracted from the roots of Inula racemosa Hook |
title_short | Aliphatic and eudesmalolide esters extracted from the roots of Inula racemosa Hook |
title_sort | aliphatic and eudesmalolide esters extracted from the roots of inula racemosa hook |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969657/ https://www.ncbi.nlm.nih.gov/pubmed/24695458 http://dx.doi.org/10.4103/0973-1296.126657 |
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