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pH-responsive mesoporous silica nanoparticles employed in controlled drug delivery systems for cancer treatment
In the fight against cancer, controlled drug delivery systems have emerged to enhance the therapeutic efficacy and safety of anti-cancer drugs. Among these systems, mesoporous silica nanoparticles (MSNs) with a functional surface possess obvious advantages and were thus rapidly developed for cancer...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Chinese Anti-Cancer Association
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969802/ https://www.ncbi.nlm.nih.gov/pubmed/24738037 http://dx.doi.org/10.7497/j.issn.2095-3941.2014.01.003 |
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author | Yang, Ke-Ni Zhang, Chun-Qiu Wang, Wei Wang, Paul C. Zhou, Jian-Ping Liang, Xing-Jie |
author_facet | Yang, Ke-Ni Zhang, Chun-Qiu Wang, Wei Wang, Paul C. Zhou, Jian-Ping Liang, Xing-Jie |
author_sort | Yang, Ke-Ni |
collection | PubMed |
description | In the fight against cancer, controlled drug delivery systems have emerged to enhance the therapeutic efficacy and safety of anti-cancer drugs. Among these systems, mesoporous silica nanoparticles (MSNs) with a functional surface possess obvious advantages and were thus rapidly developed for cancer treatment. Many stimuli-responsive materials, such as nanoparticles, polymers, and inorganic materials, have been applied as caps and gatekeepers to control drug release from MSNs. This review presents an overview of the recent progress in the production of pH-responsive MSNs based on the pH gradient between normal tissues and the tumor microenvironment. Four main categories of gatekeepers can respond to acidic conditions. These categories will be described in detail. |
format | Online Article Text |
id | pubmed-3969802 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Chinese Anti-Cancer Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-39698022014-04-15 pH-responsive mesoporous silica nanoparticles employed in controlled drug delivery systems for cancer treatment Yang, Ke-Ni Zhang, Chun-Qiu Wang, Wei Wang, Paul C. Zhou, Jian-Ping Liang, Xing-Jie Cancer Biol Med Review In the fight against cancer, controlled drug delivery systems have emerged to enhance the therapeutic efficacy and safety of anti-cancer drugs. Among these systems, mesoporous silica nanoparticles (MSNs) with a functional surface possess obvious advantages and were thus rapidly developed for cancer treatment. Many stimuli-responsive materials, such as nanoparticles, polymers, and inorganic materials, have been applied as caps and gatekeepers to control drug release from MSNs. This review presents an overview of the recent progress in the production of pH-responsive MSNs based on the pH gradient between normal tissues and the tumor microenvironment. Four main categories of gatekeepers can respond to acidic conditions. These categories will be described in detail. Chinese Anti-Cancer Association 2014-03 /pmc/articles/PMC3969802/ /pubmed/24738037 http://dx.doi.org/10.7497/j.issn.2095-3941.2014.01.003 Text en 2014 Cancer Biology & Medicine This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Review Yang, Ke-Ni Zhang, Chun-Qiu Wang, Wei Wang, Paul C. Zhou, Jian-Ping Liang, Xing-Jie pH-responsive mesoporous silica nanoparticles employed in controlled drug delivery systems for cancer treatment |
title | pH-responsive mesoporous silica nanoparticles employed in controlled drug delivery systems for cancer treatment |
title_full | pH-responsive mesoporous silica nanoparticles employed in controlled drug delivery systems for cancer treatment |
title_fullStr | pH-responsive mesoporous silica nanoparticles employed in controlled drug delivery systems for cancer treatment |
title_full_unstemmed | pH-responsive mesoporous silica nanoparticles employed in controlled drug delivery systems for cancer treatment |
title_short | pH-responsive mesoporous silica nanoparticles employed in controlled drug delivery systems for cancer treatment |
title_sort | ph-responsive mesoporous silica nanoparticles employed in controlled drug delivery systems for cancer treatment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969802/ https://www.ncbi.nlm.nih.gov/pubmed/24738037 http://dx.doi.org/10.7497/j.issn.2095-3941.2014.01.003 |
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