Antibody-directed coupling of endoglin and MMP-14 is a key mechanism for endoglin shedding and deregulation of TGF-β signaling

Endoglin is a transforming growth factor β (TGF-β) coreceptor that serves as a prognostic, diagnostic and therapeutic vascular target in human cancer. A number of endoglin ectodomain-targeting antibodies (Abs) can effectively suppress both normal and tumor-associated angiogenesis, but their molecula...

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Detalles Bibliográficos
Autores principales: Kumar, S, Pan, C C, Bloodworth, J C, Nixon, A B, Theuer, C, Hoyt, D G, Lee, N Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969897/
https://www.ncbi.nlm.nih.gov/pubmed/24077288
http://dx.doi.org/10.1038/onc.2013.386

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