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A key role for neuropeptide Y in lifespan extension and cancer suppression via dietary restriction
Knowledge of genes essential for the life-extending effect of dietary restriction (DR) in mammals is incomplete. In this study, we found that neuropeptide Y (Npy), which mediates physiological adaptations to energy deficits, is an essential link between DR and longevity in mice. The lifespan-prolong...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970128/ https://www.ncbi.nlm.nih.gov/pubmed/24682105 http://dx.doi.org/10.1038/srep04517 |
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author | Chiba, Takuya Tamashiro, Yukari Park, Daeui Kusudo, Tatsuya Fujie, Ryoko Komatsu, Toshimitsu Kim, Sang Eun Park, Seongjoon Hayashi, Hiroko Mori, Ryoichi Yamashita, Hitoshi Chung, Hae Young Shimokawa, Isao |
author_facet | Chiba, Takuya Tamashiro, Yukari Park, Daeui Kusudo, Tatsuya Fujie, Ryoko Komatsu, Toshimitsu Kim, Sang Eun Park, Seongjoon Hayashi, Hiroko Mori, Ryoichi Yamashita, Hitoshi Chung, Hae Young Shimokawa, Isao |
author_sort | Chiba, Takuya |
collection | PubMed |
description | Knowledge of genes essential for the life-extending effect of dietary restriction (DR) in mammals is incomplete. In this study, we found that neuropeptide Y (Npy), which mediates physiological adaptations to energy deficits, is an essential link between DR and longevity in mice. The lifespan-prolonging effect of lifelong 30% DR was attenuated in Npy-null mice, as was the effect on the occurrence of spontaneous tumors and oxidative stress responses in comparison to wild-type mice. In contrast, the physiological processes activated during adaptation to DR, including inhibition of anabolic signaling molecules (insulin and insulin-like growth factor-1), modulation of adipokine and corticosterone levels, and preferential fatty acid oxidation, were unaffected by the absence of Npy. These results suggest a key role for Npy in mediating the effects of DR. We also provide evidence that most of the physiological adaptations to DR could be achieved in mice without Npy. |
format | Online Article Text |
id | pubmed-3970128 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-39701282014-04-01 A key role for neuropeptide Y in lifespan extension and cancer suppression via dietary restriction Chiba, Takuya Tamashiro, Yukari Park, Daeui Kusudo, Tatsuya Fujie, Ryoko Komatsu, Toshimitsu Kim, Sang Eun Park, Seongjoon Hayashi, Hiroko Mori, Ryoichi Yamashita, Hitoshi Chung, Hae Young Shimokawa, Isao Sci Rep Article Knowledge of genes essential for the life-extending effect of dietary restriction (DR) in mammals is incomplete. In this study, we found that neuropeptide Y (Npy), which mediates physiological adaptations to energy deficits, is an essential link between DR and longevity in mice. The lifespan-prolonging effect of lifelong 30% DR was attenuated in Npy-null mice, as was the effect on the occurrence of spontaneous tumors and oxidative stress responses in comparison to wild-type mice. In contrast, the physiological processes activated during adaptation to DR, including inhibition of anabolic signaling molecules (insulin and insulin-like growth factor-1), modulation of adipokine and corticosterone levels, and preferential fatty acid oxidation, were unaffected by the absence of Npy. These results suggest a key role for Npy in mediating the effects of DR. We also provide evidence that most of the physiological adaptations to DR could be achieved in mice without Npy. Nature Publishing Group 2014-03-31 /pmc/articles/PMC3970128/ /pubmed/24682105 http://dx.doi.org/10.1038/srep04517 Text en Copyright © 2014, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported license. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
spellingShingle | Article Chiba, Takuya Tamashiro, Yukari Park, Daeui Kusudo, Tatsuya Fujie, Ryoko Komatsu, Toshimitsu Kim, Sang Eun Park, Seongjoon Hayashi, Hiroko Mori, Ryoichi Yamashita, Hitoshi Chung, Hae Young Shimokawa, Isao A key role for neuropeptide Y in lifespan extension and cancer suppression via dietary restriction |
title | A key role for neuropeptide Y in lifespan extension and cancer suppression via dietary restriction |
title_full | A key role for neuropeptide Y in lifespan extension and cancer suppression via dietary restriction |
title_fullStr | A key role for neuropeptide Y in lifespan extension and cancer suppression via dietary restriction |
title_full_unstemmed | A key role for neuropeptide Y in lifespan extension and cancer suppression via dietary restriction |
title_short | A key role for neuropeptide Y in lifespan extension and cancer suppression via dietary restriction |
title_sort | key role for neuropeptide y in lifespan extension and cancer suppression via dietary restriction |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970128/ https://www.ncbi.nlm.nih.gov/pubmed/24682105 http://dx.doi.org/10.1038/srep04517 |
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