B Cell Response and Mechanisms of Antibody Protection to West Nile Virus

West Nile virus (WNV) has become the principal cause of viral encephalitis in North America since its introduction in New York in 1999. This emerging virus is transmitted to humans via the bite of an infected mosquito. While there have been several candidates in clinical trials, there are no approve...

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Detalles Bibliográficos
Autores principales: Austin, S. Kyle, Dowd, Kimberly A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970136/
https://www.ncbi.nlm.nih.gov/pubmed/24594676
http://dx.doi.org/10.3390/v6031015
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author Austin, S. Kyle
Dowd, Kimberly A.
author_facet Austin, S. Kyle
Dowd, Kimberly A.
author_sort Austin, S. Kyle
collection PubMed
description West Nile virus (WNV) has become the principal cause of viral encephalitis in North America since its introduction in New York in 1999. This emerging virus is transmitted to humans via the bite of an infected mosquito. While there have been several candidates in clinical trials, there are no approved vaccines or WNV-specific therapies for the treatment of WNV disease in humans. From studies with small animal models and convalescent human patients, a great deal has been learned concerning the immune response to infection with WNV. Here, we provide an overview of a subset of that information regarding the humoral and antibody response generated during WNV infection.
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spelling pubmed-39701362014-03-31 B Cell Response and Mechanisms of Antibody Protection to West Nile Virus Austin, S. Kyle Dowd, Kimberly A. Viruses Review West Nile virus (WNV) has become the principal cause of viral encephalitis in North America since its introduction in New York in 1999. This emerging virus is transmitted to humans via the bite of an infected mosquito. While there have been several candidates in clinical trials, there are no approved vaccines or WNV-specific therapies for the treatment of WNV disease in humans. From studies with small animal models and convalescent human patients, a great deal has been learned concerning the immune response to infection with WNV. Here, we provide an overview of a subset of that information regarding the humoral and antibody response generated during WNV infection. MDPI 2014-03-03 /pmc/articles/PMC3970136/ /pubmed/24594676 http://dx.doi.org/10.3390/v6031015 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Austin, S. Kyle
Dowd, Kimberly A.
B Cell Response and Mechanisms of Antibody Protection to West Nile Virus
title B Cell Response and Mechanisms of Antibody Protection to West Nile Virus
title_full B Cell Response and Mechanisms of Antibody Protection to West Nile Virus
title_fullStr B Cell Response and Mechanisms of Antibody Protection to West Nile Virus
title_full_unstemmed B Cell Response and Mechanisms of Antibody Protection to West Nile Virus
title_short B Cell Response and Mechanisms of Antibody Protection to West Nile Virus
title_sort b cell response and mechanisms of antibody protection to west nile virus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970136/
https://www.ncbi.nlm.nih.gov/pubmed/24594676
http://dx.doi.org/10.3390/v6031015
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