Mitochondrial DNA (mtDNA) haplotypes and dysfunctions in presbyacusis

The aim of this study was to investigate the presence of mitochondrial DNA (mtDNA) alterations and metabolic dysfunctions in patients with presbyacusis, and to discover correlations between presbyacusis and the degree of hearing loss and mitochondrial damage. Seventy patients with presbyacusis were...

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Autores principales: MOSTAFA, H., SAAD, M., EL-ATTAR, A., AHMED, G., BERRETTINI, S., FORLI, F., SICILIANO, G., MANCUSO, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pacini Editore SpA 2014
Materias:
Basic Research in Otolaryngology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970225/
https://www.ncbi.nlm.nih.gov/pubmed/24711684
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author MOSTAFA, H.
SAAD, M.
EL-ATTAR, A.
AHMED, G.
BERRETTINI, S.
FORLI, F.
SICILIANO, G.
MANCUSO, M.
author_facet MOSTAFA, H.
SAAD, M.
EL-ATTAR, A.
AHMED, G.
BERRETTINI, S.
FORLI, F.
SICILIANO, G.
MANCUSO, M.
author_sort MOSTAFA, H.
collection PubMed
description The aim of this study was to investigate the presence of mitochondrial DNA (mtDNA) alterations and metabolic dysfunctions in patients with presbyacusis, and to discover correlations between presbyacusis and the degree of hearing loss and mitochondrial damage. Seventy patients with presbyacusis were examined, including 40 Egyptian patients and 30 Italian patients. Forty eight normal subjects were included as control group, including 24 Egyptians and 24 Italians. There was no common point mutation, and A1555G, A3243G, A7445G not were detected in any patients or controls. Haplogroup U was significantly common in patients in comparison to controls. Mutation of antioxidant genes (GSTT1, GSTM1) were significantly present in only Italian patients compared to Italian controls.
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spelling pubmed-39702252014-04-07 Mitochondrial DNA (mtDNA) haplotypes and dysfunctions in presbyacusis MOSTAFA, H. SAAD, M. EL-ATTAR, A. AHMED, G. BERRETTINI, S. FORLI, F. SICILIANO, G. MANCUSO, M. Acta Otorhinolaryngol Ital Basic Research in Otolaryngology The aim of this study was to investigate the presence of mitochondrial DNA (mtDNA) alterations and metabolic dysfunctions in patients with presbyacusis, and to discover correlations between presbyacusis and the degree of hearing loss and mitochondrial damage. Seventy patients with presbyacusis were examined, including 40 Egyptian patients and 30 Italian patients. Forty eight normal subjects were included as control group, including 24 Egyptians and 24 Italians. There was no common point mutation, and A1555G, A3243G, A7445G not were detected in any patients or controls. Haplogroup U was significantly common in patients in comparison to controls. Mutation of antioxidant genes (GSTT1, GSTM1) were significantly present in only Italian patients compared to Italian controls. Pacini Editore SpA 2014-02 /pmc/articles/PMC3970225/ /pubmed/24711684 Text en © Copyright by Società Italiana di Otorinolaringologia e Chirurgia Cervico-Facciale http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License, which permits for noncommercial use, distribution, and reproduction in any digital medium, provided the original work is properly cited and is not altered in any way. For details, please refer to http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Basic Research in Otolaryngology
MOSTAFA, H.
SAAD, M.
EL-ATTAR, A.
AHMED, G.
BERRETTINI, S.
FORLI, F.
SICILIANO, G.
MANCUSO, M.
Mitochondrial DNA (mtDNA) haplotypes and dysfunctions in presbyacusis
title Mitochondrial DNA (mtDNA) haplotypes and dysfunctions in presbyacusis
title_full Mitochondrial DNA (mtDNA) haplotypes and dysfunctions in presbyacusis
title_fullStr Mitochondrial DNA (mtDNA) haplotypes and dysfunctions in presbyacusis
title_full_unstemmed Mitochondrial DNA (mtDNA) haplotypes and dysfunctions in presbyacusis
title_short Mitochondrial DNA (mtDNA) haplotypes and dysfunctions in presbyacusis
title_sort mitochondrial dna (mtdna) haplotypes and dysfunctions in presbyacusis
topic Basic Research in Otolaryngology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970225/
https://www.ncbi.nlm.nih.gov/pubmed/24711684
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