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Effectiveness of Bortezomib in Cardiac AL Amyloidosis: A Report of Two Cases
Cardiac involvement is a major prognostic determinant in patients with primary AL amyloidosis. The clinical results of standard therapeutic approaches are suboptimal. It has been recently shown that bortezomib, an inhibitor of the proteasome, can induce rapid favourable responses in AL amyloidosis i...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970246/ https://www.ncbi.nlm.nih.gov/pubmed/24715916 http://dx.doi.org/10.1155/2014/627474 |
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author | Nigrelli, Santi Curciarello, Giuseppe Ballo, Piercarlo Michelassi, Stefano Pizzarelli, Francesco |
author_facet | Nigrelli, Santi Curciarello, Giuseppe Ballo, Piercarlo Michelassi, Stefano Pizzarelli, Francesco |
author_sort | Nigrelli, Santi |
collection | PubMed |
description | Cardiac involvement is a major prognostic determinant in patients with primary AL amyloidosis. The clinical results of standard therapeutic approaches are suboptimal. It has been recently shown that bortezomib, an inhibitor of the proteasome, can induce rapid favourable responses in AL amyloidosis improving cardiac function and survival. Herein we report on two patients with cardiac amyloidosis treated by bortezomib who experienced partial or total remission of hematologic disease and of cardiac involvement. However, death of one patient, suffering from chronic kidney disease stage 5, due to fulminant respiratory syndrome suggests the need for caution in bortezomib use if patients have this comorbid condition. |
format | Online Article Text |
id | pubmed-3970246 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39702462014-04-08 Effectiveness of Bortezomib in Cardiac AL Amyloidosis: A Report of Two Cases Nigrelli, Santi Curciarello, Giuseppe Ballo, Piercarlo Michelassi, Stefano Pizzarelli, Francesco Case Rep Med Case Report Cardiac involvement is a major prognostic determinant in patients with primary AL amyloidosis. The clinical results of standard therapeutic approaches are suboptimal. It has been recently shown that bortezomib, an inhibitor of the proteasome, can induce rapid favourable responses in AL amyloidosis improving cardiac function and survival. Herein we report on two patients with cardiac amyloidosis treated by bortezomib who experienced partial or total remission of hematologic disease and of cardiac involvement. However, death of one patient, suffering from chronic kidney disease stage 5, due to fulminant respiratory syndrome suggests the need for caution in bortezomib use if patients have this comorbid condition. Hindawi Publishing Corporation 2014 2014-03-10 /pmc/articles/PMC3970246/ /pubmed/24715916 http://dx.doi.org/10.1155/2014/627474 Text en Copyright © 2014 Santi Nigrelli et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Nigrelli, Santi Curciarello, Giuseppe Ballo, Piercarlo Michelassi, Stefano Pizzarelli, Francesco Effectiveness of Bortezomib in Cardiac AL Amyloidosis: A Report of Two Cases |
title | Effectiveness of Bortezomib in Cardiac AL Amyloidosis: A Report of Two Cases |
title_full | Effectiveness of Bortezomib in Cardiac AL Amyloidosis: A Report of Two Cases |
title_fullStr | Effectiveness of Bortezomib in Cardiac AL Amyloidosis: A Report of Two Cases |
title_full_unstemmed | Effectiveness of Bortezomib in Cardiac AL Amyloidosis: A Report of Two Cases |
title_short | Effectiveness of Bortezomib in Cardiac AL Amyloidosis: A Report of Two Cases |
title_sort | effectiveness of bortezomib in cardiac al amyloidosis: a report of two cases |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970246/ https://www.ncbi.nlm.nih.gov/pubmed/24715916 http://dx.doi.org/10.1155/2014/627474 |
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