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Ectopic Fat Assessment Focusing on Cardiometabolic and Renal Risk

It is well known that people with high levels of body fat are at higher risk for developing diabetes mellitus, kidney disease, and cardiovascular disorders. Since individuals who are slightly overweight, or even individuals of normal weight, can vary in body fat distribution, their metabolic profile...

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Detalles Bibliográficos
Autor principal: Lim, Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Endocrine Society 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970272/
https://www.ncbi.nlm.nih.gov/pubmed/24741447
http://dx.doi.org/10.3803/EnM.2014.29.1.1
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author Lim, Soo
author_facet Lim, Soo
author_sort Lim, Soo
collection PubMed
description It is well known that people with high levels of body fat are at higher risk for developing diabetes mellitus, kidney disease, and cardiovascular disorders. Since individuals who are slightly overweight, or even individuals of normal weight, can vary in body fat distribution, their metabolic profiles and the degree of association of these profiles with cardiometabolic risk factors may differ. Fat distribution might be more of a predictive factor for cardiorenometabolic risk than obesity itself, which has led researchers to investigate whether ectopic fat accumulation may partially account for the development of cardiorenometabolic disorders. In addition to visceral obesity, fat can accumulate in the liver and muscle, and these intrahepatic and intramuscular lipid stores are associated with insulin resistance and adverse metabolic phenotypes. More recently, pericardial fat, perivascular fat, and perirenal fat were found to be associated with coronary atherosclerosis, cardiovascular diseases, and kidney damage, respectively. Thus, regional fat distribution may play a key role in understanding the development of cardiorenometabolic diseases in nonobese people.
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spelling pubmed-39702722014-04-16 Ectopic Fat Assessment Focusing on Cardiometabolic and Renal Risk Lim, Soo Endocrinol Metab (Seoul) Namgok Lecture 2013 It is well known that people with high levels of body fat are at higher risk for developing diabetes mellitus, kidney disease, and cardiovascular disorders. Since individuals who are slightly overweight, or even individuals of normal weight, can vary in body fat distribution, their metabolic profiles and the degree of association of these profiles with cardiometabolic risk factors may differ. Fat distribution might be more of a predictive factor for cardiorenometabolic risk than obesity itself, which has led researchers to investigate whether ectopic fat accumulation may partially account for the development of cardiorenometabolic disorders. In addition to visceral obesity, fat can accumulate in the liver and muscle, and these intrahepatic and intramuscular lipid stores are associated with insulin resistance and adverse metabolic phenotypes. More recently, pericardial fat, perivascular fat, and perirenal fat were found to be associated with coronary atherosclerosis, cardiovascular diseases, and kidney damage, respectively. Thus, regional fat distribution may play a key role in understanding the development of cardiorenometabolic diseases in nonobese people. Korean Endocrine Society 2014-03 2014-03-14 /pmc/articles/PMC3970272/ /pubmed/24741447 http://dx.doi.org/10.3803/EnM.2014.29.1.1 Text en Copyright © 2014 Korean Endocrine Society http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Namgok Lecture 2013
Lim, Soo
Ectopic Fat Assessment Focusing on Cardiometabolic and Renal Risk
title Ectopic Fat Assessment Focusing on Cardiometabolic and Renal Risk
title_full Ectopic Fat Assessment Focusing on Cardiometabolic and Renal Risk
title_fullStr Ectopic Fat Assessment Focusing on Cardiometabolic and Renal Risk
title_full_unstemmed Ectopic Fat Assessment Focusing on Cardiometabolic and Renal Risk
title_short Ectopic Fat Assessment Focusing on Cardiometabolic and Renal Risk
title_sort ectopic fat assessment focusing on cardiometabolic and renal risk
topic Namgok Lecture 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970272/
https://www.ncbi.nlm.nih.gov/pubmed/24741447
http://dx.doi.org/10.3803/EnM.2014.29.1.1
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