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Central Pontine and Extrapontine Myelinolysis: The Great Masquerader—An Autopsy Case Report
Central pontine myelinolysis is a demyelinating disorder characterized by the loss of myelin in the center of the basis pontis usually caused by rapid correction of chronic hyponatremia. The clinical features vary depending on the extent of involvement. Demyelination can occur outside the pons as we...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970353/ https://www.ncbi.nlm.nih.gov/pubmed/24716023 http://dx.doi.org/10.1155/2014/745347 |
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author | Jacob, Sajish Gupta, Harsh Nikolic, Dejan Gundogdu, Betul Ong, Shirley |
author_facet | Jacob, Sajish Gupta, Harsh Nikolic, Dejan Gundogdu, Betul Ong, Shirley |
author_sort | Jacob, Sajish |
collection | PubMed |
description | Central pontine myelinolysis is a demyelinating disorder characterized by the loss of myelin in the center of the basis pontis usually caused by rapid correction of chronic hyponatremia. The clinical features vary depending on the extent of involvement. Demyelination can occur outside the pons as well and diagnosis can be challenging if both pontine and extrapontine areas are involved. We herein report a case of myelinolysis involving pons, lateral geniculate bodies, subependymal region, and spinal cord. To the best of our knowledge, this case represents the second case of spinal cord involvement in osmotic demyelination syndrome and the first case of involvement of thoracic region of spinal cord. |
format | Online Article Text |
id | pubmed-3970353 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39703532014-04-08 Central Pontine and Extrapontine Myelinolysis: The Great Masquerader—An Autopsy Case Report Jacob, Sajish Gupta, Harsh Nikolic, Dejan Gundogdu, Betul Ong, Shirley Case Rep Neurol Med Case Report Central pontine myelinolysis is a demyelinating disorder characterized by the loss of myelin in the center of the basis pontis usually caused by rapid correction of chronic hyponatremia. The clinical features vary depending on the extent of involvement. Demyelination can occur outside the pons as well and diagnosis can be challenging if both pontine and extrapontine areas are involved. We herein report a case of myelinolysis involving pons, lateral geniculate bodies, subependymal region, and spinal cord. To the best of our knowledge, this case represents the second case of spinal cord involvement in osmotic demyelination syndrome and the first case of involvement of thoracic region of spinal cord. Hindawi Publishing Corporation 2014 2014-03-04 /pmc/articles/PMC3970353/ /pubmed/24716023 http://dx.doi.org/10.1155/2014/745347 Text en Copyright © 2014 Sajish Jacob et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Jacob, Sajish Gupta, Harsh Nikolic, Dejan Gundogdu, Betul Ong, Shirley Central Pontine and Extrapontine Myelinolysis: The Great Masquerader—An Autopsy Case Report |
title | Central Pontine and Extrapontine Myelinolysis: The Great Masquerader—An Autopsy Case Report |
title_full | Central Pontine and Extrapontine Myelinolysis: The Great Masquerader—An Autopsy Case Report |
title_fullStr | Central Pontine and Extrapontine Myelinolysis: The Great Masquerader—An Autopsy Case Report |
title_full_unstemmed | Central Pontine and Extrapontine Myelinolysis: The Great Masquerader—An Autopsy Case Report |
title_short | Central Pontine and Extrapontine Myelinolysis: The Great Masquerader—An Autopsy Case Report |
title_sort | central pontine and extrapontine myelinolysis: the great masquerader—an autopsy case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970353/ https://www.ncbi.nlm.nih.gov/pubmed/24716023 http://dx.doi.org/10.1155/2014/745347 |
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