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Inflammatory Bowel Disease Associated Colorectal Neoplasia
Patients with ulcerative colitis (UC) or Crohn’s colitis have a greater risk for developing colorectal cancer (CRC). Many studies have described the evolving epidemiology and risk factors for CRC in patients with inflammatory bowel disease (IBD). Recent evidence indicates that the incidence has been...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970563/ https://www.ncbi.nlm.nih.gov/pubmed/24696788 http://dx.doi.org/10.4172/2161-069X.S8-002 |
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author | Vu, Michelle Chang, Jyh-Yau Chen, Jeremy Shih, David Q. |
author_facet | Vu, Michelle Chang, Jyh-Yau Chen, Jeremy Shih, David Q. |
author_sort | Vu, Michelle |
collection | PubMed |
description | Patients with ulcerative colitis (UC) or Crohn’s colitis have a greater risk for developing colorectal cancer (CRC). Many studies have described the evolving epidemiology and risk factors for CRC in patients with inflammatory bowel disease (IBD). Recent evidence indicates that the incidence has been decreasing with the advancement of medical and surgical therapies, and surveillance has emerged as the foundation of prevention. Chemoprophylaxis is another area of research; however, given the limited efficacy of these agents, they are only being used in conjunction with endoscopic surveillance. Our ability to formulate effective strategies for the prevention of this dreaded complication expands as more is discovered of the molecular events underlying IBD carcinogenesis. Management strategies are constantly updated as new evidence and endoscopic techniques emerge. In this paper, we review the literature regarding epidemiology, pathogenesis, risk factors and chemoprophylaxis as well as the latest consensus guidelines for management of dysplasia and neoplasia in IBD patients. |
format | Online Article Text |
id | pubmed-3970563 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
record_format | MEDLINE/PubMed |
spelling | pubmed-39705632014-03-31 Inflammatory Bowel Disease Associated Colorectal Neoplasia Vu, Michelle Chang, Jyh-Yau Chen, Jeremy Shih, David Q. J Gastrointest Dig Syst Article Patients with ulcerative colitis (UC) or Crohn’s colitis have a greater risk for developing colorectal cancer (CRC). Many studies have described the evolving epidemiology and risk factors for CRC in patients with inflammatory bowel disease (IBD). Recent evidence indicates that the incidence has been decreasing with the advancement of medical and surgical therapies, and surveillance has emerged as the foundation of prevention. Chemoprophylaxis is another area of research; however, given the limited efficacy of these agents, they are only being used in conjunction with endoscopic surveillance. Our ability to formulate effective strategies for the prevention of this dreaded complication expands as more is discovered of the molecular events underlying IBD carcinogenesis. Management strategies are constantly updated as new evidence and endoscopic techniques emerge. In this paper, we review the literature regarding epidemiology, pathogenesis, risk factors and chemoprophylaxis as well as the latest consensus guidelines for management of dysplasia and neoplasia in IBD patients. 2012-01-23 /pmc/articles/PMC3970563/ /pubmed/24696788 http://dx.doi.org/10.4172/2161-069X.S8-002 Text en Copyright: © 2012 Vila JJ, et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided are original author and source are credited. |
spellingShingle | Article Vu, Michelle Chang, Jyh-Yau Chen, Jeremy Shih, David Q. Inflammatory Bowel Disease Associated Colorectal Neoplasia |
title | Inflammatory Bowel Disease Associated Colorectal Neoplasia |
title_full | Inflammatory Bowel Disease Associated Colorectal Neoplasia |
title_fullStr | Inflammatory Bowel Disease Associated Colorectal Neoplasia |
title_full_unstemmed | Inflammatory Bowel Disease Associated Colorectal Neoplasia |
title_short | Inflammatory Bowel Disease Associated Colorectal Neoplasia |
title_sort | inflammatory bowel disease associated colorectal neoplasia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970563/ https://www.ncbi.nlm.nih.gov/pubmed/24696788 http://dx.doi.org/10.4172/2161-069X.S8-002 |
work_keys_str_mv | AT vumichelle inflammatoryboweldiseaseassociatedcolorectalneoplasia AT changjyhyau inflammatoryboweldiseaseassociatedcolorectalneoplasia AT chenjeremy inflammatoryboweldiseaseassociatedcolorectalneoplasia AT shihdavidq inflammatoryboweldiseaseassociatedcolorectalneoplasia |