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Inflammatory Bowel Disease Associated Colorectal Neoplasia

Patients with ulcerative colitis (UC) or Crohn’s colitis have a greater risk for developing colorectal cancer (CRC). Many studies have described the evolving epidemiology and risk factors for CRC in patients with inflammatory bowel disease (IBD). Recent evidence indicates that the incidence has been...

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Autores principales: Vu, Michelle, Chang, Jyh-Yau, Chen, Jeremy, Shih, David Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970563/
https://www.ncbi.nlm.nih.gov/pubmed/24696788
http://dx.doi.org/10.4172/2161-069X.S8-002
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author Vu, Michelle
Chang, Jyh-Yau
Chen, Jeremy
Shih, David Q.
author_facet Vu, Michelle
Chang, Jyh-Yau
Chen, Jeremy
Shih, David Q.
author_sort Vu, Michelle
collection PubMed
description Patients with ulcerative colitis (UC) or Crohn’s colitis have a greater risk for developing colorectal cancer (CRC). Many studies have described the evolving epidemiology and risk factors for CRC in patients with inflammatory bowel disease (IBD). Recent evidence indicates that the incidence has been decreasing with the advancement of medical and surgical therapies, and surveillance has emerged as the foundation of prevention. Chemoprophylaxis is another area of research; however, given the limited efficacy of these agents, they are only being used in conjunction with endoscopic surveillance. Our ability to formulate effective strategies for the prevention of this dreaded complication expands as more is discovered of the molecular events underlying IBD carcinogenesis. Management strategies are constantly updated as new evidence and endoscopic techniques emerge. In this paper, we review the literature regarding epidemiology, pathogenesis, risk factors and chemoprophylaxis as well as the latest consensus guidelines for management of dysplasia and neoplasia in IBD patients.
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spelling pubmed-39705632014-03-31 Inflammatory Bowel Disease Associated Colorectal Neoplasia Vu, Michelle Chang, Jyh-Yau Chen, Jeremy Shih, David Q. J Gastrointest Dig Syst Article Patients with ulcerative colitis (UC) or Crohn’s colitis have a greater risk for developing colorectal cancer (CRC). Many studies have described the evolving epidemiology and risk factors for CRC in patients with inflammatory bowel disease (IBD). Recent evidence indicates that the incidence has been decreasing with the advancement of medical and surgical therapies, and surveillance has emerged as the foundation of prevention. Chemoprophylaxis is another area of research; however, given the limited efficacy of these agents, they are only being used in conjunction with endoscopic surveillance. Our ability to formulate effective strategies for the prevention of this dreaded complication expands as more is discovered of the molecular events underlying IBD carcinogenesis. Management strategies are constantly updated as new evidence and endoscopic techniques emerge. In this paper, we review the literature regarding epidemiology, pathogenesis, risk factors and chemoprophylaxis as well as the latest consensus guidelines for management of dysplasia and neoplasia in IBD patients. 2012-01-23 /pmc/articles/PMC3970563/ /pubmed/24696788 http://dx.doi.org/10.4172/2161-069X.S8-002 Text en Copyright: © 2012 Vila JJ, et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided are original author and source are credited.
spellingShingle Article
Vu, Michelle
Chang, Jyh-Yau
Chen, Jeremy
Shih, David Q.
Inflammatory Bowel Disease Associated Colorectal Neoplasia
title Inflammatory Bowel Disease Associated Colorectal Neoplasia
title_full Inflammatory Bowel Disease Associated Colorectal Neoplasia
title_fullStr Inflammatory Bowel Disease Associated Colorectal Neoplasia
title_full_unstemmed Inflammatory Bowel Disease Associated Colorectal Neoplasia
title_short Inflammatory Bowel Disease Associated Colorectal Neoplasia
title_sort inflammatory bowel disease associated colorectal neoplasia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970563/
https://www.ncbi.nlm.nih.gov/pubmed/24696788
http://dx.doi.org/10.4172/2161-069X.S8-002
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