Comparison of the infectivity of Trypanosoma cruzi insect-derived metacyclic trypomastigotes after mucosal and cutaneous contaminative challenges

Trypanosoma cruzi infects humans when infected triatomine vector excreta contaminate breaks in skin or mucosal surfaces. T. cruzi insect-derived metacyclic trypomastigotes (IMT) invade through gastric mucosa after oral challenges without any visible inflammatory changes, while cutaneous and conjunct...

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Detalles Bibliográficos
Autores principales: Eickhoff, Christopher Steven, Dunn, Brian Anthony, Sullivan, Nicole Lea, Hoft, Daniel Fredric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2013
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970623/
https://www.ncbi.nlm.nih.gov/pubmed/23828001
http://dx.doi.org/10.1590/0074-0276108042013018
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author Eickhoff, Christopher Steven
Dunn, Brian Anthony
Sullivan, Nicole Lea
Hoft, Daniel Fredric
author_facet Eickhoff, Christopher Steven
Dunn, Brian Anthony
Sullivan, Nicole Lea
Hoft, Daniel Fredric
author_sort Eickhoff, Christopher Steven
collection PubMed
description Trypanosoma cruzi infects humans when infected triatomine vector excreta contaminate breaks in skin or mucosal surfaces. T. cruzi insect-derived metacyclic trypomastigotes (IMT) invade through gastric mucosa after oral challenges without any visible inflammatory changes, while cutaneous and conjunctival infections result in obvious local physical signs. In this study we compared the infectivity of T. cruzi IMT in mice after cutaneous and oral contaminative challenges simulating natural infections. The 50% infective dose (ID50) for oral challenge was 100 fold lower than the ID50for cutaneous challenge, indicating that oral mucosal transmission is more efficient than cutaneous transmission.
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spelling pubmed-39706232014-05-21 Comparison of the infectivity of Trypanosoma cruzi insect-derived metacyclic trypomastigotes after mucosal and cutaneous contaminative challenges Eickhoff, Christopher Steven Dunn, Brian Anthony Sullivan, Nicole Lea Hoft, Daniel Fredric Mem Inst Oswaldo Cruz Short Communications Trypanosoma cruzi infects humans when infected triatomine vector excreta contaminate breaks in skin or mucosal surfaces. T. cruzi insect-derived metacyclic trypomastigotes (IMT) invade through gastric mucosa after oral challenges without any visible inflammatory changes, while cutaneous and conjunctival infections result in obvious local physical signs. In this study we compared the infectivity of T. cruzi IMT in mice after cutaneous and oral contaminative challenges simulating natural infections. The 50% infective dose (ID50) for oral challenge was 100 fold lower than the ID50for cutaneous challenge, indicating that oral mucosal transmission is more efficient than cutaneous transmission. Instituto Oswaldo Cruz, Ministério da Saúde 2013-06 /pmc/articles/PMC3970623/ /pubmed/23828001 http://dx.doi.org/10.1590/0074-0276108042013018 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communications
Eickhoff, Christopher Steven
Dunn, Brian Anthony
Sullivan, Nicole Lea
Hoft, Daniel Fredric
Comparison of the infectivity of Trypanosoma cruzi insect-derived metacyclic trypomastigotes after mucosal and cutaneous contaminative challenges
title Comparison of the infectivity of Trypanosoma cruzi insect-derived metacyclic trypomastigotes after mucosal and cutaneous contaminative challenges
title_full Comparison of the infectivity of Trypanosoma cruzi insect-derived metacyclic trypomastigotes after mucosal and cutaneous contaminative challenges
title_fullStr Comparison of the infectivity of Trypanosoma cruzi insect-derived metacyclic trypomastigotes after mucosal and cutaneous contaminative challenges
title_full_unstemmed Comparison of the infectivity of Trypanosoma cruzi insect-derived metacyclic trypomastigotes after mucosal and cutaneous contaminative challenges
title_short Comparison of the infectivity of Trypanosoma cruzi insect-derived metacyclic trypomastigotes after mucosal and cutaneous contaminative challenges
title_sort comparison of the infectivity of trypanosoma cruzi insect-derived metacyclic trypomastigotes after mucosal and cutaneous contaminative challenges
topic Short Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970623/
https://www.ncbi.nlm.nih.gov/pubmed/23828001
http://dx.doi.org/10.1590/0074-0276108042013018
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