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A conserved MCM single-stranded DNA binding element is essential for replication initiation

The ring-shaped MCM helicase is essential to all phases of DNA replication. The complex loads at replication origins as an inactive double-hexamer encircling duplex DNA. Helicase activation converts this species to two active single hexamers that encircle single-stranded DNA (ssDNA). The molecular d...

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Detalles Bibliográficos
Autores principales:	Froelich, Clifford A, Kang, Sukhyun, Epling, Leslie B, Bell, Stephen P, Enemark, Eric J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2014
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970758/ https://www.ncbi.nlm.nih.gov/pubmed/24692448 http://dx.doi.org/10.7554/eLife.01993

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