Cargando…

Xanthine Oxidase Inhibition by Febuxostat Attenuates Experimental Atherosclerosis in Mice

Atherosclerosis is a chronic inflammatory disease due to lipid deposition in the arterial wall. Multiple mechanisms participate in the inflammatory process, including oxidative stress. Xanthine oxidase (XO) is a major source of reactive oxygen species (ROS) and has been linked to the pathogenesis of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nomura, Johji, Busso, Nathalie, Ives, Annette, Matsui, Chieko, Tsujimoto, Syunsuke, Shirakura, Takashi, Tamura, Mizuho, Kobayashi, Tsunefumi, So, Alexander, Yamanaka, Yoshihiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971401/ https://www.ncbi.nlm.nih.gov/pubmed/24686534 http://dx.doi.org/10.1038/srep04554

Ejemplares similares

Febuxostat, an Inhibitor of Xanthine Oxidase, Suppresses Lipopolysaccharide-Induced MCP-1 Production via MAPK Phosphatase-1-Mediated Inactivation of JNK
por: Nomura, Johji, et al.
Publicado: (2013)

Febuxostat, a novel xanthine oxidoreductase inhibitor, improves hypertension and endothelial dysfunction in spontaneously hypertensive rats
por: Shirakura, Takashi, et al.
Publicado: (2016)

Febuxostat, a Xanthine Oxidoreductase Inhibitor, Decreases NLRP3-dependent Inflammation in Macrophages by Activating the Purine Salvage Pathway and Restoring Cellular Bioenergetics
por: Nomura, Johji, et al.
Publicado: (2019)

Side Effects and Interactions of the Xanthine Oxidase Inhibitor Febuxostat
por: Jordan, Andreas, et al.
Publicado: (2018)

The potential renoprotection of xanthine oxidase inhibitors: Febuxostat versus allopurinol
por: Ryu, Dong-Ryeol
Publicado: (2017)

The Xanthine Oxidase Inhibitor Febuxostat Suppresses Adipogenesis and Activates Nrf2
por: Higa, Yoshiki, et al.
Publicado: (2023)

Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation
por: Ives, Annette, et al.
Publicado: (2015)

Cardio-renal protective effect of the xanthine oxidase inhibitor febuxostat in the 5/6 nephrectomy model with hyperuricemia
por: Omizo, Hiroki, et al.
Publicado: (2020)

Febuxostat, a Xanthine Oxidase Inhibitor, Decreased Macrophage Matrix Metalloproteinase Expression in Hypoxia
por: Wei, Shuoyu, et al.
Publicado: (2020)

Activity of xanthine oxidase in plasma correlates with indices of insulin resistance and liver dysfunction in patients with type 2 diabetes mellitus and metabolic syndrome: A pilot exploratory study
por: Sunagawa, Sumito, et al.
Publicado: (2018)

Xanthine oxidase inhibition by febuxostat attenuates stress-induced hyperuricemia, glucose dysmetabolism, and prothrombotic state in mice
por: Yisireyili, Maimaiti, et al.
Publicado: (2017)

Xanthine oxidase inhibition attenuates insulin resistance and diet-induced steatohepatitis in mice
por: Nishikawa, Tomoki, et al.
Publicado: (2020)

Long-Term Inhibition of Xanthine Oxidase by Febuxostat Does Not Decrease Blood Pressure in Deoxycorticosterone Acetate (DOCA)-Salt Hypertensive Rats
por: Szasz, Theodora, et al.
Publicado: (2013)

Integrated in silico – in vitro strategy for the discovery of potential xanthine oxidase inhibitors from Egyptian propolis and their synergistic effect with allopurinol and febuxostat
por: Ghallab, Dina S., et al.
Publicado: (2022)

Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth
por: Kusano, Teruo, et al.
Publicado: (2019)

Xanthine Oxidase Inhibitor Febuxostat Exerts an Anti-Inflammatory Action and Protects against Diabetic Nephropathy Development in KK-Ay Obese Diabetic Mice
por: Mizuno, Yu, et al.
Publicado: (2019)

Xanthine oxidase inhibitors and sepsis
por: Ramos, Maria Fátima de Paula, et al.
Publicado: (2018)

Xanthine Oxidase Mediates Axonal and Myelin Loss in a Murine Model of Multiple Sclerosis
por: Honorat, Josephe Archie, et al.
Publicado: (2013)

Rationale and design of a multicenter randomized study for evaluating vascular function under uric acid control using the xanthine oxidase inhibitor, febuxostat: the PRIZE study
por: Oyama, Jun-ichi, et al.
Publicado: (2016)

XANTHINE OXIDASE ACTIVITY IN REGENERATING LIVER
por: Feigelson, Muriel, et al.
Publicado: (1957)

Study of Drug Metabolism by Xanthine Oxidase
por: Zhao, Jing, et al.
Publicado: (2012)

Xanthine Oxidase—A Personal History
por: Hille, Russ
Publicado: (2023)

The Xanthine Oxidase Inhibitor Febuxostat Suppresses the Progression of IgA Nephropathy, Possibly via Its Anti-Inflammatory and Anti-Fibrotic Effects in the gddY Mouse Model
por: Inoue, Masa-Ki, et al.
Publicado: (2018)

Xanthine oxidase and aldehyde oxidase contribute to allopurinol metabolism in rats
por: Tayama, Yoshitaka, et al.
Publicado: (2022)

Different inhibitory potency of febuxostat towards mammalian and bacterial xanthine oxidoreductases: insight from molecular dynamics
por: Kikuchi, Hiroto, et al.
Publicado: (2012)

The mechanism and significance of the conversion of xanthine dehydrogenase to xanthine oxidase in mammalian secretory gland cells
por: Kusano, Teruo, et al.
Publicado: (2022)

Xanthine Oxidase and Uric Acid in Atrial Fibrillation
por: Korantzopoulos, Panagiotis, et al.
Publicado: (2012)

The impact of xanthine oxidase (XO) on hemolytic diseases
por: Schmidt, Heidi M., et al.
Publicado: (2018)

Renoprotective Effect of Xanthine Oxidase Inhibitor, Topiroxostat
por: Katsuyama, Hisayuki, et al.
Publicado: (2019)

Xanthine oxidase inhibitors in ischaemic heart disease
por: Zdrenghea, Mihnea, et al.
Publicado: (2017)

Reassessing the Safety Profile of Lesinurad in Combination with Xanthine Oxidase Inhibitor Therapy
por: Perez-Ruiz, Fernando, et al.
Publicado: (2019)

Conversion of xanthine dehydrogenase to xanthine oxidase as a possible marker for hypoxia in tumours and normal tissues.
por: Anderson, R. F., et al.
Publicado: (1989)

Inhibition of Xanthine Oxidase-Catalyzed Xanthine and 6-Mercaptopurine Oxidation by Flavonoid Aglycones and Some of Their Conjugates
por: Mohos, Violetta, et al.
Publicado: (2020)

Xanthine oxidase acitivity in progressive spontaneous mammary carcinogenesis.
por: Sheth, N. A., et al.
Publicado: (1968)

Structure–Activity Relationship of Xanthones as Inhibitors of Xanthine Oxidase
por: Zhou, Ling-Yun, et al.
Publicado: (2018)

Implication of changes in xanthine oxidase activity following hemodialysis
por: Fujioka, Hayato, et al.
Publicado: (2023)

Xanthine Oxidoreductase Is Involved in Chondrocyte Mineralization and Expressed in Osteoarthritic Damaged Cartilage
por: Nasi, Sonia, et al.
Publicado: (2021)

Febuxostat ameliorates secondary progressive experimental autoimmune encephalomyelitis by restoring mitochondrial energy production in a GOT2-dependent manner
por: Honorat, Josephe A., et al.
Publicado: (2017)

Xanthine Oxidase Inhibitor, Febuxostat Is Effective against 5-Fluorouracil-Induced Parotid Salivary Gland Injury in Rats Via Inhibition of Oxidative Stress, Inflammation and Targeting TRPC1/CHOP Signalling Pathway
por: Abdelzaher, Walaa Yehia, et al.
Publicado: (2022)

Mobilization of xanthine oxidase from the gastrointestinal tract in acute pancreatitis
por: Granell, Susana, et al.
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_8naj5pfppshcf2jblqd4bstuac