TFIIB-Related Factor 2 Is Associated with Poor Prognosis of Nonsmall Cell Lung Cancer Patients through Promoting Tumor Epithelial-Mesenchymal Transition

In this study, we found that increased BRF2 protein expression was prevalent in NSCLC. Overexpression of BRF2 correlated with abnormal expression of E-cadherin, N-cadherin, and snail. Additionally, expression of BRF2 was found to be an independent prognostic factor in NSCLC patients. Furthermore, we...

Descripción completa

Detalles Bibliográficos
Autores principales: Tian, Yu, Lu, Ming, Yue, Weiming, Li, Lin, Li, Shuhai, Gao, Cun, Si, Libo, Qi, Lei, Hu, Wensi, Tian, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971564/
https://www.ncbi.nlm.nih.gov/pubmed/24738062
http://dx.doi.org/10.1155/2014/530786
_version_ 1782309493976072192
author Tian, Yu
Lu, Ming
Yue, Weiming
Li, Lin
Li, Shuhai
Gao, Cun
Si, Libo
Qi, Lei
Hu, Wensi
Tian, Hui
author_facet Tian, Yu
Lu, Ming
Yue, Weiming
Li, Lin
Li, Shuhai
Gao, Cun
Si, Libo
Qi, Lei
Hu, Wensi
Tian, Hui
author_sort Tian, Yu
collection PubMed
description In this study, we found that increased BRF2 protein expression was prevalent in NSCLC. Overexpression of BRF2 correlated with abnormal expression of E-cadherin, N-cadherin, and snail. Additionally, expression of BRF2 was found to be an independent prognostic factor in NSCLC patients. Furthermore, we showed that targeted knockdown of BRF2 expression could inhibit the migratory and invasive abilities of NSCLC cells and induced loss of the epithelial-mesenchymal transition of NSCLC cells. These results suggested that BRF2 overexpression in tumor tissues is significantly associated with the poor prognosis of NSCLC patients through promoting epithelial-mesenchymal transition (EMT) program.
format Online
Article
Text
id pubmed-3971564
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-39715642014-04-15 TFIIB-Related Factor 2 Is Associated with Poor Prognosis of Nonsmall Cell Lung Cancer Patients through Promoting Tumor Epithelial-Mesenchymal Transition Tian, Yu Lu, Ming Yue, Weiming Li, Lin Li, Shuhai Gao, Cun Si, Libo Qi, Lei Hu, Wensi Tian, Hui Biomed Res Int Research Article In this study, we found that increased BRF2 protein expression was prevalent in NSCLC. Overexpression of BRF2 correlated with abnormal expression of E-cadherin, N-cadherin, and snail. Additionally, expression of BRF2 was found to be an independent prognostic factor in NSCLC patients. Furthermore, we showed that targeted knockdown of BRF2 expression could inhibit the migratory and invasive abilities of NSCLC cells and induced loss of the epithelial-mesenchymal transition of NSCLC cells. These results suggested that BRF2 overexpression in tumor tissues is significantly associated with the poor prognosis of NSCLC patients through promoting epithelial-mesenchymal transition (EMT) program. Hindawi Publishing Corporation 2014 2014-03-17 /pmc/articles/PMC3971564/ /pubmed/24738062 http://dx.doi.org/10.1155/2014/530786 Text en Copyright © 2014 Yu Tian et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Tian, Yu
Lu, Ming
Yue, Weiming
Li, Lin
Li, Shuhai
Gao, Cun
Si, Libo
Qi, Lei
Hu, Wensi
Tian, Hui
TFIIB-Related Factor 2 Is Associated with Poor Prognosis of Nonsmall Cell Lung Cancer Patients through Promoting Tumor Epithelial-Mesenchymal Transition
title TFIIB-Related Factor 2 Is Associated with Poor Prognosis of Nonsmall Cell Lung Cancer Patients through Promoting Tumor Epithelial-Mesenchymal Transition
title_full TFIIB-Related Factor 2 Is Associated with Poor Prognosis of Nonsmall Cell Lung Cancer Patients through Promoting Tumor Epithelial-Mesenchymal Transition
title_fullStr TFIIB-Related Factor 2 Is Associated with Poor Prognosis of Nonsmall Cell Lung Cancer Patients through Promoting Tumor Epithelial-Mesenchymal Transition
title_full_unstemmed TFIIB-Related Factor 2 Is Associated with Poor Prognosis of Nonsmall Cell Lung Cancer Patients through Promoting Tumor Epithelial-Mesenchymal Transition
title_short TFIIB-Related Factor 2 Is Associated with Poor Prognosis of Nonsmall Cell Lung Cancer Patients through Promoting Tumor Epithelial-Mesenchymal Transition
title_sort tfiib-related factor 2 is associated with poor prognosis of nonsmall cell lung cancer patients through promoting tumor epithelial-mesenchymal transition
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971564/
https://www.ncbi.nlm.nih.gov/pubmed/24738062
http://dx.doi.org/10.1155/2014/530786
work_keys_str_mv AT tianyu tfiibrelatedfactor2isassociatedwithpoorprognosisofnonsmallcelllungcancerpatientsthroughpromotingtumorepithelialmesenchymaltransition
AT luming tfiibrelatedfactor2isassociatedwithpoorprognosisofnonsmallcelllungcancerpatientsthroughpromotingtumorepithelialmesenchymaltransition
AT yueweiming tfiibrelatedfactor2isassociatedwithpoorprognosisofnonsmallcelllungcancerpatientsthroughpromotingtumorepithelialmesenchymaltransition
AT lilin tfiibrelatedfactor2isassociatedwithpoorprognosisofnonsmallcelllungcancerpatientsthroughpromotingtumorepithelialmesenchymaltransition
AT lishuhai tfiibrelatedfactor2isassociatedwithpoorprognosisofnonsmallcelllungcancerpatientsthroughpromotingtumorepithelialmesenchymaltransition
AT gaocun tfiibrelatedfactor2isassociatedwithpoorprognosisofnonsmallcelllungcancerpatientsthroughpromotingtumorepithelialmesenchymaltransition
AT silibo tfiibrelatedfactor2isassociatedwithpoorprognosisofnonsmallcelllungcancerpatientsthroughpromotingtumorepithelialmesenchymaltransition
AT qilei tfiibrelatedfactor2isassociatedwithpoorprognosisofnonsmallcelllungcancerpatientsthroughpromotingtumorepithelialmesenchymaltransition
AT huwensi tfiibrelatedfactor2isassociatedwithpoorprognosisofnonsmallcelllungcancerpatientsthroughpromotingtumorepithelialmesenchymaltransition
AT tianhui tfiibrelatedfactor2isassociatedwithpoorprognosisofnonsmallcelllungcancerpatientsthroughpromotingtumorepithelialmesenchymaltransition

Ejemplares similares