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Choroidal thickness in patients with diabetic retinopathy
PURPOSE: The aim of the study reported here was to assess choroidal thickness (CT) and central macular thickness (CMT) in patients with diabetic retinopathy. MATERIALS AND METHODS: A total of 151 eyes from 80 patients from the retina department of Istanbul Training and Research Hospital who had type...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove Medical Press
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971934/ https://www.ncbi.nlm.nih.gov/pubmed/24707168 http://dx.doi.org/10.2147/OPTH.S59395 |
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author | Ünsal, Erkan Eltutar, Kadir Zirtiloğlu, Sibel Dinçer, Nurhan Özdoğan Erkul, Sezin Güngel, Hülya |
author_facet | Ünsal, Erkan Eltutar, Kadir Zirtiloğlu, Sibel Dinçer, Nurhan Özdoğan Erkul, Sezin Güngel, Hülya |
author_sort | Ünsal, Erkan |
collection | PubMed |
description | PURPOSE: The aim of the study reported here was to assess choroidal thickness (CT) and central macular thickness (CMT) in patients with diabetic retinopathy. MATERIALS AND METHODS: A total of 151 eyes from 80 patients from the retina department of Istanbul Training and Research Hospital who had type 2 diabetes mellitus with diabetic retinopathy were studied retrospectively in this cross-sectional research. Patients were divided into three groups: mild–moderate nonproliferative diabetic retinopathy without macular edema (NPDR), mild–moderate nonproliferative diabetic retinopathy with macular edema (DME), and proliferative diabetic retinopathy (PDR). In addition, 40 eyes of 20 healthy individuals comprised a control group. Choroidal thickness was measured from the posterior edge of the retinal pigment epithelium to the choroid/sclera junction at 500-μm intervals up to 1,500 μm temporal and nasal to the fovea. The CMT measurement was obtained for each eye. Serum hemoglobin A(1c) (HbA(1c)) levels were measured. RESULTS: The study included 191 eyes, comprising 151 eyes of 80 patients and 40 eyes of 20 healthy individuals. Of the 151 patient eyes, 61 had NPDR, 62 had PDR, and 28 eyes had DME. There was no statistically significant difference in age between the groups (P>0.05). In both the PDR and DME groups, the CT was statistically significantly decreased compared with the control group (P<0.001, P<0.001 for the PDR and DME groups, respectively). The mean CMT in the DME group was increased significantly compared with both the NPDR and PDR groups (P<0.001, P<0.001, respectively). In all three groups, serum HbA(1c) levels were found to be increased significantly compared with the control group (P=0.000). We found a statistically weak–moderate negative correlation between central macular and foveal CT (r=−289, P=0.000). There was a statistically strong correlation between CMT and HbA(1c) levels (r=0.577, P=0.483) and a statistically weak–moderate negative correlation between the central CT and HbA(1c) levels (r=−0.331, P<0.001). CONCLUSION: Diabetes changes the CT. CT was found to be significantly decreased in the DME and PDR groups. |
format | Online Article Text |
id | pubmed-3971934 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-39719342014-04-04 Choroidal thickness in patients with diabetic retinopathy Ünsal, Erkan Eltutar, Kadir Zirtiloğlu, Sibel Dinçer, Nurhan Özdoğan Erkul, Sezin Güngel, Hülya Clin Ophthalmol Original Research PURPOSE: The aim of the study reported here was to assess choroidal thickness (CT) and central macular thickness (CMT) in patients with diabetic retinopathy. MATERIALS AND METHODS: A total of 151 eyes from 80 patients from the retina department of Istanbul Training and Research Hospital who had type 2 diabetes mellitus with diabetic retinopathy were studied retrospectively in this cross-sectional research. Patients were divided into three groups: mild–moderate nonproliferative diabetic retinopathy without macular edema (NPDR), mild–moderate nonproliferative diabetic retinopathy with macular edema (DME), and proliferative diabetic retinopathy (PDR). In addition, 40 eyes of 20 healthy individuals comprised a control group. Choroidal thickness was measured from the posterior edge of the retinal pigment epithelium to the choroid/sclera junction at 500-μm intervals up to 1,500 μm temporal and nasal to the fovea. The CMT measurement was obtained for each eye. Serum hemoglobin A(1c) (HbA(1c)) levels were measured. RESULTS: The study included 191 eyes, comprising 151 eyes of 80 patients and 40 eyes of 20 healthy individuals. Of the 151 patient eyes, 61 had NPDR, 62 had PDR, and 28 eyes had DME. There was no statistically significant difference in age between the groups (P>0.05). In both the PDR and DME groups, the CT was statistically significantly decreased compared with the control group (P<0.001, P<0.001 for the PDR and DME groups, respectively). The mean CMT in the DME group was increased significantly compared with both the NPDR and PDR groups (P<0.001, P<0.001, respectively). In all three groups, serum HbA(1c) levels were found to be increased significantly compared with the control group (P=0.000). We found a statistically weak–moderate negative correlation between central macular and foveal CT (r=−289, P=0.000). There was a statistically strong correlation between CMT and HbA(1c) levels (r=0.577, P=0.483) and a statistically weak–moderate negative correlation between the central CT and HbA(1c) levels (r=−0.331, P<0.001). CONCLUSION: Diabetes changes the CT. CT was found to be significantly decreased in the DME and PDR groups. Dove Medical Press 2014-03-27 /pmc/articles/PMC3971934/ /pubmed/24707168 http://dx.doi.org/10.2147/OPTH.S59395 Text en © 2014 Ünsal et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Ünsal, Erkan Eltutar, Kadir Zirtiloğlu, Sibel Dinçer, Nurhan Özdoğan Erkul, Sezin Güngel, Hülya Choroidal thickness in patients with diabetic retinopathy |
title | Choroidal thickness in patients with diabetic retinopathy |
title_full | Choroidal thickness in patients with diabetic retinopathy |
title_fullStr | Choroidal thickness in patients with diabetic retinopathy |
title_full_unstemmed | Choroidal thickness in patients with diabetic retinopathy |
title_short | Choroidal thickness in patients with diabetic retinopathy |
title_sort | choroidal thickness in patients with diabetic retinopathy |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971934/ https://www.ncbi.nlm.nih.gov/pubmed/24707168 http://dx.doi.org/10.2147/OPTH.S59395 |
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