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Choroidal thickness in patients with diabetic retinopathy

PURPOSE: The aim of the study reported here was to assess choroidal thickness (CT) and central macular thickness (CMT) in patients with diabetic retinopathy. MATERIALS AND METHODS: A total of 151 eyes from 80 patients from the retina department of Istanbul Training and Research Hospital who had type...

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Autores principales: Ünsal, Erkan, Eltutar, Kadir, Zirtiloğlu, Sibel, Dinçer, Nurhan, Özdoğan Erkul, Sezin, Güngel, Hülya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971934/
https://www.ncbi.nlm.nih.gov/pubmed/24707168
http://dx.doi.org/10.2147/OPTH.S59395
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author Ünsal, Erkan
Eltutar, Kadir
Zirtiloğlu, Sibel
Dinçer, Nurhan
Özdoğan Erkul, Sezin
Güngel, Hülya
author_facet Ünsal, Erkan
Eltutar, Kadir
Zirtiloğlu, Sibel
Dinçer, Nurhan
Özdoğan Erkul, Sezin
Güngel, Hülya
author_sort Ünsal, Erkan
collection PubMed
description PURPOSE: The aim of the study reported here was to assess choroidal thickness (CT) and central macular thickness (CMT) in patients with diabetic retinopathy. MATERIALS AND METHODS: A total of 151 eyes from 80 patients from the retina department of Istanbul Training and Research Hospital who had type 2 diabetes mellitus with diabetic retinopathy were studied retrospectively in this cross-sectional research. Patients were divided into three groups: mild–moderate nonproliferative diabetic retinopathy without macular edema (NPDR), mild–moderate nonproliferative diabetic retinopathy with macular edema (DME), and proliferative diabetic retinopathy (PDR). In addition, 40 eyes of 20 healthy individuals comprised a control group. Choroidal thickness was measured from the posterior edge of the retinal pigment epithelium to the choroid/sclera junction at 500-μm intervals up to 1,500 μm temporal and nasal to the fovea. The CMT measurement was obtained for each eye. Serum hemoglobin A(1c) (HbA(1c)) levels were measured. RESULTS: The study included 191 eyes, comprising 151 eyes of 80 patients and 40 eyes of 20 healthy individuals. Of the 151 patient eyes, 61 had NPDR, 62 had PDR, and 28 eyes had DME. There was no statistically significant difference in age between the groups (P>0.05). In both the PDR and DME groups, the CT was statistically significantly decreased compared with the control group (P<0.001, P<0.001 for the PDR and DME groups, respectively). The mean CMT in the DME group was increased significantly compared with both the NPDR and PDR groups (P<0.001, P<0.001, respectively). In all three groups, serum HbA(1c) levels were found to be increased significantly compared with the control group (P=0.000). We found a statistically weak–moderate negative correlation between central macular and foveal CT (r=−289, P=0.000). There was a statistically strong correlation between CMT and HbA(1c) levels (r=0.577, P=0.483) and a statistically weak–moderate negative correlation between the central CT and HbA(1c) levels (r=−0.331, P<0.001). CONCLUSION: Diabetes changes the CT. CT was found to be significantly decreased in the DME and PDR groups.
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spelling pubmed-39719342014-04-04 Choroidal thickness in patients with diabetic retinopathy Ünsal, Erkan Eltutar, Kadir Zirtiloğlu, Sibel Dinçer, Nurhan Özdoğan Erkul, Sezin Güngel, Hülya Clin Ophthalmol Original Research PURPOSE: The aim of the study reported here was to assess choroidal thickness (CT) and central macular thickness (CMT) in patients with diabetic retinopathy. MATERIALS AND METHODS: A total of 151 eyes from 80 patients from the retina department of Istanbul Training and Research Hospital who had type 2 diabetes mellitus with diabetic retinopathy were studied retrospectively in this cross-sectional research. Patients were divided into three groups: mild–moderate nonproliferative diabetic retinopathy without macular edema (NPDR), mild–moderate nonproliferative diabetic retinopathy with macular edema (DME), and proliferative diabetic retinopathy (PDR). In addition, 40 eyes of 20 healthy individuals comprised a control group. Choroidal thickness was measured from the posterior edge of the retinal pigment epithelium to the choroid/sclera junction at 500-μm intervals up to 1,500 μm temporal and nasal to the fovea. The CMT measurement was obtained for each eye. Serum hemoglobin A(1c) (HbA(1c)) levels were measured. RESULTS: The study included 191 eyes, comprising 151 eyes of 80 patients and 40 eyes of 20 healthy individuals. Of the 151 patient eyes, 61 had NPDR, 62 had PDR, and 28 eyes had DME. There was no statistically significant difference in age between the groups (P>0.05). In both the PDR and DME groups, the CT was statistically significantly decreased compared with the control group (P<0.001, P<0.001 for the PDR and DME groups, respectively). The mean CMT in the DME group was increased significantly compared with both the NPDR and PDR groups (P<0.001, P<0.001, respectively). In all three groups, serum HbA(1c) levels were found to be increased significantly compared with the control group (P=0.000). We found a statistically weak–moderate negative correlation between central macular and foveal CT (r=−289, P=0.000). There was a statistically strong correlation between CMT and HbA(1c) levels (r=0.577, P=0.483) and a statistically weak–moderate negative correlation between the central CT and HbA(1c) levels (r=−0.331, P<0.001). CONCLUSION: Diabetes changes the CT. CT was found to be significantly decreased in the DME and PDR groups. Dove Medical Press 2014-03-27 /pmc/articles/PMC3971934/ /pubmed/24707168 http://dx.doi.org/10.2147/OPTH.S59395 Text en © 2014 Ünsal et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Ünsal, Erkan
Eltutar, Kadir
Zirtiloğlu, Sibel
Dinçer, Nurhan
Özdoğan Erkul, Sezin
Güngel, Hülya
Choroidal thickness in patients with diabetic retinopathy
title Choroidal thickness in patients with diabetic retinopathy
title_full Choroidal thickness in patients with diabetic retinopathy
title_fullStr Choroidal thickness in patients with diabetic retinopathy
title_full_unstemmed Choroidal thickness in patients with diabetic retinopathy
title_short Choroidal thickness in patients with diabetic retinopathy
title_sort choroidal thickness in patients with diabetic retinopathy
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971934/
https://www.ncbi.nlm.nih.gov/pubmed/24707168
http://dx.doi.org/10.2147/OPTH.S59395
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