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Conformational Activation of Poly(ADP-ribose) Polymerase-1 upon DNA Binding Revealed by Small-Angle X-ray Scattering

[Image: see text] Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear protein that plays key roles in several fundamental cellular processes. PARP-1 catalyzes the polymerization of nicotinamide adenine dinucleotide on itself and other acceptor proteins, forming long branched poly(ADP-ribose) polymer...

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Detalles Bibliográficos
Autores principales:	Mansoorabadi, Steven O., Wu, Meilan, Tao, Zhihua, Gao, Peng, Pingali, Sai Venkatesh, Guo, Liang, Liu, Hung-wen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971956/ https://www.ncbi.nlm.nih.gov/pubmed/24588584 http://dx.doi.org/10.1021/bi401439n

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