Base Excision Repair of Chemotherapeutically-Induced Alkylated DNA Damage Predominantly Causes Contractions of Expanded GAA Repeats Associated with Friedreich's Ataxia

Expansion of GAA·TTC repeats within the first intron of the frataxin gene is the cause of Friedreich's ataxia (FRDA), an autosomal recessive neurodegenerative disorder. However, no effective treatment for the disease has been developed as yet. In this study, we explored a possibility of shorten...

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Detalles Bibliográficos
Autores principales: Lai, Yanhao, Beaver, Jill M., Lorente, Karla, Melo, Jonathan, Ramjagsingh, Shyama, Agoulnik, Irina U., Zhang, Zunzhen, Liu, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972099/
https://www.ncbi.nlm.nih.gov/pubmed/24691413
http://dx.doi.org/10.1371/journal.pone.0093464

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