Fetal Cyclophosphamide Exposure Induces Testicular Cancer and Reduced Spermatogenesis and Ovarian Follicle Numbers in Mice

Exposure to radiation during fetal development induces testicular germ cell tumors (TGCT) and reduces spermatogenesis in mice. However, whether DNA damaging chemotherapeutic agents elicit these effects in mice remains unclear. Among such agents, cyclophosphamide (CP) is currently used to treat breas...

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Detalles Bibliográficos
Autores principales: Comish, Paul B., Drumond, Ana Luiza, Kinnell, Hazel L., Anderson, Richard A., Matin, Angabin, Meistrich, Marvin L., Shetty, Gunapala
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972108/
https://www.ncbi.nlm.nih.gov/pubmed/24691397
http://dx.doi.org/10.1371/journal.pone.0093311

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