VASP Activation via the Gα13/RhoA/PKA Pathway Mediates Cucurbitacin-B-Induced Actin Aggregation and Cofilin-Actin Rod Formation

Cucurbitacin B (CuB), a potent antineoplastic agent of cucurbitacin triterpenoids, induces rapid disruption of actin cytoskeleton and aberrant cell cycle inhibiting carcinogenesis. However, the underlying molecular mechanism of such anticancer effects remains incompletely understood. In this study,...

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Detalles Bibliográficos
Autores principales: Zhang, Yan-Ting, Xu, Li-Hui, Lu, Qun, Liu, Kun-Peng, Liu, Pei-Yan, Ji, Fang, Liu, Xiao-Ming, Ouyang, Dong-Yun, He, Xian-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972149/
https://www.ncbi.nlm.nih.gov/pubmed/24691407
http://dx.doi.org/10.1371/journal.pone.0093547

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972149/
https://www.ncbi.nlm.nih.gov/pubmed/24691407
http://dx.doi.org/10.1371/journal.pone.0093547

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