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Targeted Disruption of LDLR Causes Hypercholesterolemia and Atherosclerosis in Yucatan Miniature Pigs

Recent progress in engineering the genomes of large animals has spurred increased interest in developing better animal models for diseases where current options are inadequate. Here, we report the creation of Yucatan miniature pigs with targeted disruptions of the low-density lipoprotein receptor (L...

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Detalles Bibliográficos
Autores principales:	Davis, Bryan T., Wang, Xiao-Jun, Rohret, Judy A., Struzynski, Jason T., Merricks, Elizabeth P., Bellinger, Dwight A., Rohret, Frank A., Nichols, Timothy C., Rogers, Christopher S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972179/ https://www.ncbi.nlm.nih.gov/pubmed/24691380 http://dx.doi.org/10.1371/journal.pone.0093457

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