Programmed Cell Death-1 Deficiency Exacerbates T Cell Activation and Atherogenesis despite Expansion of Regulatory T Cells in Atherosclerosis-Prone Mice

T cell activation represents a double-edged sword in atherogenesis, as it promotes both pro-inflammatory T cell activation and atheroprotective Foxp3(+) regulatory T cell (Treg) responses. Here, we investigated the role of the co-inhibitory receptor programmed cell death-1 (PD-1) in T cell activatio...

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Detalles Bibliográficos
Autores principales: Cochain, Clément, Chaudhari, Sweena M., Koch, Miriam, Wiendl, Heinz, Eckstein, Hans-Henning, Zernecke, Alma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972211/
https://www.ncbi.nlm.nih.gov/pubmed/24691202
http://dx.doi.org/10.1371/journal.pone.0093280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972211/
https://www.ncbi.nlm.nih.gov/pubmed/24691202
http://dx.doi.org/10.1371/journal.pone.0093280

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